Results 131 to 140 of about 2,211,033 (313)

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

A conceptualization of complexity in IS-driven organizational transformations [PDF]

, 2013
Organizational transformations reliant on successful ICT system developments (continue to) fail to deliver projected benefits even when contemporary governance models are applied rigorously.
Schefe, Neville, Schefe, Neville Lindsay, Timbrell, Gregory T., Timbrell, Greg   +3 more
core   +1 more source

Physiographic Knowledge Acquisition: Identification, Conceptualization and Representation

, 2014
Argialas, D.P., and G.CH. Miliaresis, 1996. Physiographic Knowledge Acquisition: Identification, Conceptualization and Representation. ACSM/ASPRS, Baltimore-Maryland, April 22-25, 311-320.
George Miliaresis (554317)
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Conceptualizing Kirchnerismo

Partecipazione e Conflitto, 2017
Fil: Peruzzotti, Carlos Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
openaire   +3 more sources

Conceptualization in HRM Research and Conceptualization of HRM Research: A Simplified Conceptual Study [PDF]

Doing research has become a valuable duty of academics, a mandatory requirement to be met by the students pursuing Bachelor’s Honours Degrees, Research Master’s Degrees, and Doctoral Degrees, and an emerging responsibility, if not a duty, for ...
H. H. D. N. P. Opatha
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

TO THE QUESTION OF STATE SOLVENCY: BASIC APPROACHES TO CONCEPTUALIZATION

, 2015
To the question of state solvency: basic approaches to ...
S. V. Zhigzhitov
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Catchment data for process conceptualization: simply not enough?

, 2008
Catchment data for process conceptualization : simply not enough
Merot, P., Burns, D.A., Dunn, S. M., Tetziaff, D., Tetzlaff, D., Merlot, P., Dunn, S.M., Mérot, Philippe, Bonell, M., Laudon, Hjalmar,, Neal, C., Laudon, H., Burns, D. A., Burns, D.A, Soulsby, C., Merot, P.,, Dunn, S.M.,, Soulsby, C.,, Bonell, M.,, Tetzlaff, D.,, Swedish University of Agricultural Sciences., Neal, C.,, Burns, D. A.,   +22 more
core   +1 more source