Results 111 to 120 of about 1,966,627 (313)

Conceptualization of IoT architectures

Although there is a large interest about internet of things (IoT) architectures, still there is no consensus on their conceptualization in the extant literature.
Camplone, Jacopo, Paolone, Gaetanino, Paesani, Romolo, Di Felice, Paolino, Piazza, Andrea   +4 more
core   +1 more source

Research Conceptualization

, 2018
This chapter discusses the import of research conceptualization, documentation, and communication. The intent is to clinically exposit the importance of research and its processes, to underscore the philosophy of research and its relevance to science ...
Oyesoji Amos Aremu
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Extended Conceptualization of “Patchwork Capitalism”. In response to the discussants

, 2022
This article is devoted to the “Extended Conceptualization” of patchwork capitalism (hereinafter also referred to as PC). It constitutes the third step in work on the methodological aspect of PC. The first step was the development of a conceptualization,
Gardawski, Juliusz
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Grounding the Translation

Grounded Theory Review: An International Journal, 2009
Grounded theory research in cross-language, cross-cultural context is associated with the challenges of linguistic sensitivity of conceptualization.
Svetlana Shklarov
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Metamodeling Aspects of Model Conceptualization

, 1990
This paper suggests a technique for improving the conceptualization of models. The key aspect of this technique is to set aside the main model for a period of time during the model conceptualization process and focus on building a watchdog submodel ...
Wakeland, Wayne W.
core  

Book Review:

Grounded Theory Review: An International Journal, 2013
In the first chapter of this book, Glaser explains his purpose to help the researcher use the constant comparative method to discover and name patterns in the data, relate them to each other, generate a “conceptual hypothesis” (p.
Susan Stillman
doaj