Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Conceptualization of interaction styles in discourse: a diachronic analysis of MODESTY [PDF]
, 2017 This paper narrows in on the conceptualization of modest communicative behaviour lexicalized in the English language and discourse; in particular, it reconstructs its historical variation.
Shevchenko, I.S.
core
Using Culturally Ambitious Teaching Practices to Support Urban Mathematics Teaching and Learning [PDF]
, 2014 Culturally relevant pedagogy is an ideology upon which strong urban classrooms can be built. However, culturally relevant pedagogy has not been operationalized in a way that allows consistent implementation in classrooms.
Waddell, Lanette R
core +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Study addiction - a new area of psychological study: conceptualization, assessment, and preliminary empirical findings [PDF]
, 2015 Aims: Recent research has suggested that for some individuals, educational studying may become compulsive and excessive and lead to ‘study addiction’.
Andreassen, CS +3 more
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The importance of target audiences in the design of training actions [PDF]
, 2005 This paper describes the process of definition, conceptualization and implementation of a business course addressed for logistic and industrial managers.
Oliveira, F. M. +3 more
core +1 more source
Ancient rhetoric as a hermeneutical tool for the analysis of characterization in narrative literature [PDF]
, 2010 This article argues that the conceptualization of the notions of character and characterization in ancient rhetorical treatises can serve as a hermeneutical tool for the analysis of characterization in narrative literature.
De Temmerman, Koen
core +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source