Duplication, concerted evolution and purifying selection drive the evolution of mosquito vitellogenin genes [PDF]
Background Mosquito vitellogenin (Vtg) genes belong to a small multiple gene family that encodes the major yolk protein precursors required for egg production. Multiple Vtg genes have been cloned and characterized from several mosquito species, but their
Sakamoto Joyce M +4 more
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The extraordinary satellitome diversity of freshwater crayfish: a driver of genome evolution [PDF]
Background Repetitive elements, particularly satellite DNA (satDNA), play a significant role in genome evolution and organisation. However, their diversity and evolutionary dynamics remain poorly understood in non-model organisms.
Lena Bonassin +12 more
doaj +2 more sources
The evolution of concerted evolution [PDF]
Concerted evolution is a consequence of processes that convert copies of a gene in a multigene family into the same copy. Here we ask whether this homogenization may be adaptive.
L.D. Hurst, N.G.C. Smith
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Lack of ITS sequence homogenization in Erysimum species (Brassicaceae) with different ploidy levels
The internal transcribed spacers (ITS) exhibit concerted evolution by the fast homogenization of these sequences at the intragenomic level. However, the rate and extension of this process are unclear and might be conditioned by the number and divergence ...
Carolina Osuna-Mascaró +4 more
doaj +1 more source
OASes and STING: Adaptive Evolution in Concert [PDF]
OAS (2'-5'-oligoadenylate synthases) proteins and cyclic GMP-AMP synthase (cGAS, gene symbol: MB21D1) patrol the cytoplasm for the presence of foreign nucleic acids. Upon binding to double-stranded RNA or double-stranded DNA, OAS proteins and cGAS produce nucleotide second messengers to activate RNase L and STING (stimulator of interferon genes, gene ...
Mozzi A +7 more
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Concerted evolution of human amylase genes. [PDF]
Cosmid clones containing 250 kilobases of genomic DNA from the human amylase gene cluster have been isolated. These clones contain seven distinct amylase genes which appear to comprise the complete multigene family. By sequence comparison with the cDNAs, we have identified two pancreatic amylase genes and three salivary amylase genes.
D L, Gumucio +4 more
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Diversity and recombination of dispersed ribosomal DNA and protein coding genes in microsporidia. [PDF]
Microsporidian strains are usually classified on the basis of their ribosomal DNA (rDNA) sequences. Although rDNA occurs as multiple copies, in most non-microsporidian species copies within a genome occur as tandem arrays and are homogenised by concerted
Joseph Edward Ironside
doaj +1 more source
Ancient duplication, coevolution, and selection at the MHC class IIA and IIB genes of birds
IntroductionThe Major Histocompatibility Complex (MHC) of vertebrates is a dynamically evolving multigene family primarily responsible for recognizing non-self peptide antigens and triggering a pathogen-specific adaptive immune response.
Piotr Minias +3 more
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Understanding the Evolution of Mammalian Brain Structures; the Need for a (New) Cerebrotype Approach
The mammalian brain varies in size by a factor of 100,000 and is composed of anatomically and functionally distinct structures. Theoretically, the manner in which brain composition can evolve is limited, ranging from highly modular (“mosaic evolution ...
Romain Willemet
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Concerted Evolution of Structure and Function in a Miniature Protein [PDF]
Unstructured peptides merely garnished with moieties used for recognition rarely, if ever, possess function. By contrast, presentation of the same moieties by a globular protein can result in a high affinity ligand. Recently we described a strategy for the design of miniature functional proteins in which DNA-binding residues from the bZIP protein GCN4 ...
J W, Chin, A, Schepartz
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