Results 161 to 170 of about 77,030 (213)

[Multicomponent exercise for people at high risk of frailty in the local context]. [PDF]

Aten Primaria
Simó Sanz C, Gil Ramos S, Moncada MD.
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

[Real-world evidence on the use of generic tofacitinib in patients with rheumatoid arthritis] [PDF]

Rev Fac Cien Med Univ Nac Cordoba
Di Giuseppe LA, Burgos MA, Posadas Martínez ML, Vargas Casalles AL, Alvarez KE, Buela G, Puga MC, Soriano Guppy ER, Rosa JE.   +8 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conclusiones finales

Antigüedad y Cristianismo, 2000
José Antonio Molina Gómez
doaj  

Use of artificial intelligence in the diagnosis of alterations in cervical cytology: A university population-based observational study [PDF]

Biomedica
Manzano-Chaya JS, Mendoza-Herrera T, García-Ayala E.   +2 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

[BioSAT: Development and conceptual validation of a satisfaction questionnaire regarding biologic therapies for severe asthma through a structured patient-professional co-creation process]. [PDF]

Open Respir Arch
Álvarez-Gutiérrez FJ, Blanco Aparicio M, Casas Maldonado F, Padilla Galo A, Urrutia Landa I, Melenchón B, Muerza I, Ruisánchez M, Gómez R, Martín S.   +9 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

[Breast MRI: Kaiser score agreement with and without diffusion]. [PDF]

Rev Med Inst Mex Seguro Soc
López-Méndez JMI, Delgadillo-Cristerna R, Campiram-Gutiérrez J.   +2 more
europepmc   +1 more source