Results 211 to 220 of about 2,368,570 (246)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

[Impact of the Diagnostic and Therapeutic Assignment Model (MADiT) on the quality of care in institutionalized older adults: A quasi-experimental study]. [PDF]

Aten Primaria
Alvarado Escobar C, Duaso E, Montiel I, Colomer N, Gamboa A, Amblás J.   +5 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

[A series of poisonings due to spider bites (Latrodectus spp)]. [PDF]

Rev Med Inst Mex Seguro Soc
Castañeda-Gómez J, Delgado-Cuellar OM, Arce-Vega R, Zacarías-Rivera RD, Villegas-Trejo A, Salceda-Sánchez B, Barrientos-Medina R, Alvarado-Castro JA.   +7 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

[Association of platelets with multiple organic failure in septic patients]. [PDF]

Rev Med Inst Mex Seguro Soc
Bocanegra-Alegría E, Bravo-Santibáñez E, Márquez-Torres CB.   +2 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Resúmenes presentados al 35 Congreso de la Asociación de Cardiología Intervencionista de la Sociedad Española de Cardiología. Las Palmas de Gran Canaria, 12-14 de junio de 2024. [PDF]

REC Interv Cardiol
europepmc   +1 more source

Disseminated histoplasmosis in an HIV-positive patient mimicking advanced endometrial carcinoma. Case report [PDF]

Rev Colomb Obstet Ginecol
Limia Pérez MI, Quílez Conde JC, Beiro Felipe E, Dehesa Martínez T, Morán Cuesta F, López Matarranz M, De La Rosa Fernández JH, Pérez Verdugo CD.   +7 more
europepmc   +1 more source

Conclusiones generales 2 º Congreso Mundial Cielo Laboral 2018: “Cuarta revolución industrial y globalización: la protección del empleo, la salud y vida privada de los trabajadores ante los desafíos del futuro" [PDF]

, 2018
Sierra Benítez, Esperanza Macarena
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