Results 61 to 70 of about 9,687 (274)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Analyzing symmetric distributions by utilizing extropy measures based on order statistics

Journal of Radiation Research and Applied Sciences
Quantification of the uncertainty of distribution functions, by using entropy and extropy, is important in many statistical analyses. Inspired by this, our study uses extropy and several related measures (including the cumulative residual extropy ...
I.A. Husseiny, H.M. Barakat, M. Nagy, A.H. Mansi   +3 more
doaj   +1 more source

Do red deer stags (Cervus elaphus) use roar fundamental frequency (F0) to assess rivals? [PDF]

, 2013
It is well established that in humans, male voices are disproportionately lower pitched than female voices, and recent studies suggest that this dimorphism in fundamental frequency (F0) results from both intrasexual (male competition) and intersexual ...
AF Malo, AM Taylor, Antje Engelhardt, BD Charlton, BD Charlton, BD Charlton, BD Charlton, BD Charlton, BD Charlton, BD Charlton, BD Charlton, BD Charlton, BD Charlton, Benjamin D. Charlton, C Neumann, C Richardson, C ten Cate, C Vignal, CC Tigue, CL Apicella, CT Herbst, D Pfefferle, D Pfefferle, D Reby, D Reby, D Reby, D Reby, D Reby, D Rendall, D Rendall, DA Puts, DA Puts, DA Puts, David Reby, DR Feinberg, E Moulines, E Vannoni, E Vannoni, IR Titze, IR Titze, IR Titze, J Burgdorf, J Cynx, J Fischer, J Fischer, JC Mitani, JH Ryalls, JM Dabbs Jr, K Ishizaka, K McComb, KE McComb, KV Stopher, L Koren, LA Hardouin, LA Hardouin, M Martín-Vivaldi, MA Bee, MAP Bee, Maxime Garcia, MB Kreutzer, MD Hauser, Megan T. Wyman, MJ Owren, MK Minami, MT Wyman, MT Wyman, MVG Torriani, N Kidjo, N Masataka, NJ Lass, NS Beckford, R Mundry, S Evans, S Evans, S Sanvito, SA Collins, SE Wolff, TH Clutton-Brock, TR Harris, U Candolin, W Wagner Jr, W. Tecumseh Fitch, WT Fitch, WT Fitch, WT Fitch, Y Benjamini   +85 more
core   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Expected Sample Moments of Concomitants of Selected Order Statistics

, 2003
Reihe Computational Intelligence ...
Arnold, Dirk V., Beyer, Hans-Georg
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The influence of patient's age on clinical decision-making about coronary heart disease in the USA and the UK [PDF]

, 2006
This paper examines UK and US primary care doctors' decision-making about older (aged 75 years) and midlife (aged 55 years) patients presenting with coronary heart disease (CHD).
Adams, Ann, Arber, Sara, Buckingham, Christopher D., Link, Carol, Marceau, Lisa, McKinlay, John   +5 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source