Results 81 to 90 of about 331,242 (341)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The cumulation of intellectual property rights, with specific reference to the cumulation of patent and design rights [PDF]

Zbornik Radova Pravnog Fakulteta u Nišu
In this paper, the author first explores the terminology and systematics in the field of cumulation of intellectual property rights, in an attempt to determine the meaning of certain terms and harmonize the terminology in this field, and then analyzes ...
Milosavljević Nikola
doaj   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Problems of strategic management of processes of modernization of the Russian economy

Путеводитель предпринимателя, 2020
In this article author shows us main goals of strategic management as main mechanism of Russia social and economic development. Author especially points out necessity of space development, overcoming of excessive differentiation, managing conditions of ...

doaj  

Concurrence Measurement for the Two-Qubit Optical and Atomic States

Entropy, 2015
Concurrence provides us an effective approach to quantify entanglement, which is quite important in quantum information processing applications. In the paper, we mainly review some direct concurrence measurement protocols of the two-qubit optical or ...
Lan Zhou, Yu-Bo Sheng
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Quantum discord and entanglement in grover search algorithm

Open Physics, 2016
Imperfections and noise in realistic quantum computers may seriously affect the accuracy of quantum algorithms. In this article we explore the impact of static imperfections on quantum entanglement as well as non-entangled quantum correlations in Grover ...
Ye Bin, Zhang Tingzhong, Qiu Liang, Wang Xuesong   +3 more
doaj   +1 more source

Politiques de libéralisation financière, commerciale, institutionnelle et concurrence dans le secteur financier en RD. Congo et ses pays limitrophes [PDF]

Mouvements et Enjeux Sociaux, 2023
Cet article examine la façon dont les politiques de libéralisation financière, commerciale et institutionnelle affectent la concurrence du secteur financier en RDC et ses pays limitrophes.
Alain TENDAY LUPUMBA, Aristote KANINDA NZUZI, Serge PINDI MAYILA   +2 more
doaj  

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source