Results 71 to 80 of about 36,627 (309)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Improving Performance of a Distributed File System Using a Speculative Semantics-Based Algorithm

Tsinghua Science and Technology, 2015
File-sharing semantics is used by the file systems for sharing data among concurrent client processes in a consistent manner. Session semantics is a widely used file-sharing semantics in Distributed File Systems (DFSs).
Talluri Lakshmi Siva Rama Krishna, Thirumalaisamy Ragunathan, Sudheer Kumar Battula   +2 more
doaj   +1 more source

Probabilistic Concurrency Testing for Weak Memory Concurrency

, 2022
The artifact for paper "Probabilistic Concurrency Testing for Weak Memory Concurrency" in ...
Mingyu Gao, Burcu Kulahcioglu Ozkan, Soham Chakraborty   +2 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Concurrent sexual partnerships and associated factors: a cross-sectional population-based survey in a rural community in Africa with a generalised HIV epidemic

BMC Public Health, 2011
Background Although concurrent sexual partnerships may play an important role in HIV transmission in Africa, the lack of an agreed definition of concurrency and of standard methodological approaches has hindered studies.
Karabarinde Alex, Waswa Laban, Maher Dermot, Baisley Kathy   +3 more
doaj   +1 more source

Concurrent Metareasoning [PDF]

The Journal of Supercomputing, 2006
Metaresoning is again under focus in the AI community. Here in this paper, a new classification for types of metareasoning has been proposed. In recent years, only the ones that are here named as pre-metareasoning and para-metareasoning have been studied.
Shahriar Pourazin, Ahmad Abdollahzadeh Barforoush   +1 more
openaire   +1 more source

Cognition, Concurrency Theory and Reverberations in the Brain: in Search of a Calculus of Communicating (Recurrent) Neural Systems [PDF]

, 2011
We consider whether techniques from concurrency theory can be applied in the area of Cognitive Neuroscience. We focus on two potential applications. The first of these explores structural decomposition, which is effectively assumed by the localisation of
Bowman, Howard, Li, Su
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Could differences in implicit attitudes to sexual concurrency play a role in generalized HIV epidemics? [version 2; referees: 2 approved]

F1000Research, 2018
Background: Sexual partner concurrency has been implicated in the genesis of generalized HIV epidemic in South Africa. Most South Africans, however, disapprove of concurrency in surveys.
Chris R. Kenyon, Kenny Wolfs, Kara Osbak, Maleeto Malataliana, Guido Van Hal, Sizwe Zondo, Jacques van Lankveld   +6 more
doaj   +1 more source