Results 81 to 90 of about 97,871 (297)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

User-Centric Internet of Things and Controlled Service Scheduling Scheme for a Software-Defined Network

Applied Sciences
Mobile users can access vital real-time services through wireless paradigms like software-defined network (SDN) topologies and the Internet of Things. Point-of-contact-based infrastructures and dynamic user densities increase resource access and service ...
Mohd Anjum, Hong Min, Zubair Ahmed
doaj   +1 more source

Towards Practical Graph-Based Verification for an Object-Oriented Concurrency Model [PDF]

, 2015
To harness the power of multi-core and distributed platforms, and to make the development of concurrent software more accessible to software engineers, different object-oriented concurrency models such as SCOOP have been proposed.
Corrodi, Claudio, Heußner, Alexander, Morandi, Benjamin, Poskitt, Christopher M.   +3 more
core   +4 more sources

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Concurrent sexual partnerships and associated factors: a cross-sectional population-based survey in a rural community in Africa with a generalised HIV epidemic

BMC Public Health, 2011
Background Although concurrent sexual partnerships may play an important role in HIV transmission in Africa, the lack of an agreed definition of concurrency and of standard methodological approaches has hindered studies.
Karabarinde Alex, Waswa Laban, Maher Dermot, Baisley Kathy   +3 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Architecting software concurrency [PDF]

Computer Science Journal of Moldova, 2011
Nowadays, the majority of software systems are inherently concurrent. Anyway, internal and external concurrent activities increase the complexity of systems' behavior. Adequate architecting can significantly decrease implementation errors.
Dumitru Ciorba, Victor Besliu
doaj  

Partner concurrency and HIV infection risk in South Africa

International Journal of Infectious Diseases, 2016
Background: The relationship between concurrent sexual partnerships and HIV risk is not fully understood. Evidence on the relationship between partner concurrency (one's sexual partner has another partner) and individual HIV risk is limited.
Chris R. Kenyon, Achilleas Tsoumanis, Ilan S. Schwartz, Brendan Maughan-Brown   +3 more
doaj   +1 more source

Concurrence geometries

Advances in Mathematics, 1983
The paper deals with the problem ''to describe combinatorially the variety of configurations c of hyperplanes which can be constructed, given that the section of the configuration c on a fixed hyperplane H be a given geometric figure''. This is related to a correspondence between plane projections of polyhedra in 3-space and static stresses in the ...
openaire   +2 more sources