Results 61 to 70 of about 15,889,209 (373)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Integration of concurrency control in a language with subtyping and subclassing [PDF]

, 1995
This paper describes the integration of concurrency control in BALLOON, an object-oriented language that separates the concepts of type and class as well of subtyping and subclassing.
Baquero, Carlos, Moura, Francisco, Oliveira, Rui Carlos Mendes de   +2 more
core  

A Graph-Based Semantics Workbench for Concurrent Asynchronous Programs [PDF]

, 2016
A number of novel programming languages and libraries have been proposed that offer simpler-to-use models of concurrency than threads. It is challenging, however, to devise execution models that successfully realise their abstractions without forfeiting ...
A Corradini, A Rensink, A Rensink, AH Ghamarian, Alexander Heußner, B Meyer, B Meyer, B Morandi, D Lucanu, EB Johnsen, G Agha, G Geeraerts, G Rosu, J Armstrong, J Meseguer, J Meseguer, J Schäfer, J Tschannen, JS Ostroff, P Backes, PJ Brooke, PJ Brooke, S West, TF Şerbănuţă   +23 more
core   +3 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Token-Based Access Control

IEEE Access, 2020
Traditional centralized access control has some shortcomings in robustness, trustworthiness and circulation. Blockchains have the advantages of fault tolerance and trust.
Guohua Gan, E. Chen, Zhiyuan Zhou, Yan Zhu   +3 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Assignment of Resources in Distributed Systems [PDF]

Journal of Systemics, Cybernetics and Informatics, 2018
In distributed processing systems it is often necessary to coordinate the allocation of shared resources that should be assigned in the processes in the modality of mutual exclusion; in such cases, the order in which the shared resources will be assigned
David L. La Red Martínez, Julio C. Acosta, Federico Agostini   +2 more
doaj  

ParallelC-Assist: Productivity Accelerator Suite Based on Dynamic Instrumentation

IEEE Access, 2023
Software developers often face challenges in terms of quality and productivity to match competitive costs. The software industry seeks options to minimize this cost during different phases of software development and maintenance with improved ...
Nachiketa Chatterjee, Srijoni Majumdar, Partha Pratim Das, Amlan Chakrabarti   +3 more
doaj   +1 more source

CRDTs: Consistency without concurrency control [PDF]

, 2009
A CRDT is a data type whose operations commute when they are concurrent. Replicas of a CRDT eventually converge without any complex concurrency control. As an existence proof, we exhibit a non-trivial CRDT: a shared edit buffer called Treedoc. We outline
Letia, Mihai, Preguiça, Nuno, Shapiro, Marc   +2 more
core   +3 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source