Results 141 to 150 of about 268,236 (226)

Precise structure and polarization determination of Hf_0.5Zr_0.5O₂ with electron ptychography. [PDF]

Nat Commun
Gao X, Liu Z, Han B, Zhang X, Mao R, Shi R, Zhu R, Lu J, Wang T, Jin K, Li J, Ge C, Gao P.   +12 more
europepmc   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

AI-Driven Design of Miniproteins as Potential Allosteric Modulators. [PDF]

Pharmaceuticals (Basel)
Liu X, Sun Y, Xia Y, Li H, Yan Z.
europepmc   +1 more source

The Uppsala APP Mutation Promotes Wild‐Type Amyloid‐β Aggregation and Deposition In Vivo

Advanced Science, EarlyView.
We investigated in vivo cross‐seeding of amyloid‐β (Aβ) isoforms in transgenic mice co‐expressing wild‐typeAβ and the Uppsala‐mutant Aβ variant (AβUpp), lacking six central residues. Weleveraged MALDI‐MS imaging and hyperspectral microscopy to follow spatio‐temporalAβ deposition.
Junyue Ge, María Pagnon de la Vega, Silvia Zampar, Enrica Cerilli, Srinivas Koutarapu, Ling Wu, Paul Fraser, Sertan Arkan, Vilmantas Giedraitis, Lars Lannfelt, Greta Hultqvist, Stina Syvänen, Martin Ingelsson, Jörg Hanrieder, Dag Sehlin   +14 more
wiley   +1 more source

Classical criticality via quantum annealing. [PDF]

Nat Commun
Sathe P, King AD, Mniszewski SM, Coffrin C, Nisoli C, Caravelli F.   +5 more
europepmc   +1 more source

KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation

Advanced Science, EarlyView.
This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho, Jee Won Hwang, Gyu Hwan Hyun, Sangkyu Lee, Dae‐Geun Song, Su‐Nam Kim, Yong Kee Kim   +6 more
wiley   +1 more source

Robust helix photo-transforming in soft matter. [PDF]

Natl Sci Rev
Li M, Hu H, Zheng ZG, Niu X, Yuan C, Sun P, Liu X, Liu X, Zhang Q, Tian H, Zhu WH, Feringa BL.   +11 more
europepmc   +1 more source

Summary of the international conference on materials science and condensed matter physics

, 2007
Canţer, V.G., Kantser, V.G., Culiuc, L.L., Kulyuk, L.L.   +3 more
openaire   +1 more source

Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells

Advanced Science, EarlyView.
Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale, Luca Messina, Valeria Panzetta, Stefania Saporito, Costantino Menna, Maurizio Ventre, Paolo A. Netti   +6 more
wiley   +1 more source

Dual origin of effective axion response. [PDF]

Nat Commun
Seidov TZ, Barredo-Alamilla E, Bobylev DA, Shaposhnikov L, Mazanov M, Gorlach MA.   +5 more
europepmc   +1 more source