Synergistic effects of <i>Ferula asafoetida</i> extract and condensed tannins from raisin pomace on <i>in vitro</i> cecal fermentation kinetics and nutrient digestibility in horses. [PDF]
Dehghan H +4 more
europepmc +1 more source
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci +13 more
wiley +1 more source
Intrinsic Disorder as a Biomimetic Design Paradigm. [PDF]
Puccinelli T, Bordin JR.
europepmc +1 more source
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li +15 more
wiley +1 more source
Author Correction: Magnetically tunable selectivity in methane oxidation enabled by Fe-embedded liquid metal catalysts. [PDF]
Zhang H +18 more
europepmc +1 more source
UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro +7 more
wiley +1 more source
Computational design of class II MHC binding peptide with sequence-based evolution information. [PDF]
Cao Y, Li Y, Ren W, Li W, Yan Z.
europepmc +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
Spin-polarized triplet excitonic insulators in Ta<sub>3</sub> <i>X</i> <sub>8</sub> (<i>X</i> = I or Br) monolayers. [PDF]
Sheng H +7 more
europepmc +1 more source

