Results 151 to 160 of about 329,866 (205)
Molybdenum‐Catalyzed Asymmetric Amination of α‐Hydroxy Esters: Synthesis of α‐Amino Acids
Advanced Science, EarlyView.N‐protected unnatural α‐amino acids are synthesized from α‐hydroxy esters and amines in a Mo‐catalyzed reaction. The formation of C─N bond takes place in a highly efficient way, which can be rendered asymmetric when a chiral molybdenum‐complex and chiral phosphoric acid (CPA) are used.
Shahida Perveen +5 more
wiley +1 more source
Mechanochemistry: Fundamental Principles and Applications
Advanced Science, EarlyView.In this review, the physicochemical principles of mechanochemistry are first clarified. Based on this foundation, the research basis and cutting‐edge scientific achievements in four areas are introduced: solid‐state organic chemistry, polymers, interface science, and biomechanochemistry.
Liang Dong +4 more
wiley +1 more source
Advanced Science, EarlyView.The fusion peptide LR27‐modified thermosensitive nanodelivery system exhibits both hair cell targeting and inner ear penetrating properties. This system sustainably and effectively delivers PTH1‐34 to the inner ear of a hearing loss mouse model via the synergistic effects of multiple peptides, achieving satisfactory hearing protection through ...
Jiawen Li +12 more
wiley +1 more source
Advanced Science, EarlyView.A precise self‐assembly of fullerene‐like V60‐MOP constructed from the first discovered polyoxovanadates five‐membered ring V5 units is discovered. In situ modifications are successfully used to insert {MO5} (M = V/Mo) in the center of the V5 ring, resulting in three other isomorphic spherical cages V66‐MOP, V72‐MOP, and V60Mo12‐MOP.
Hongmei Gan +5 more
wiley +1 more source
Advanced Science, EarlyView.LACK156‐173 is internalized into RA‐FLSs via CAPN2‐mediated endocytosis and inhibits the aggressive phenotype of RA‐FLSs by restoring dysregulated fatty acid synthesis metabolism mediated by overexpressed FASN. The findings suggest that targeting the restoration of fatty acid metabolism could potentially alleviate synovial invasion and joint damage in ...
Jianling Su +17 more
wiley +1 more source
The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti‐Tumor Effector Cytotoxic T Cells
Advanced Science, EarlyView.RARα is highly expressed by differentiated effector and exhausted T cells and exerts a negative effect on effector T cell differentiation and the associated trafficking receptor switch. Upregulated RARα levels decrease the nuclear histone acetylase (HAT) activity, and this suppresses the expression of key Teff transcription factor BATF and trafficking ...
Patrick Niekamp +5 more
wiley +1 more source
Advancements in Biochar as a Sustainable Adsorbent for Water Pollution Mitigation
Advanced Science, EarlyView.Biochar, obtained through pyrolysis of organic waste, serves as a sustainable solution for wastewater treatment due to its adaptability and low‐cost nature. This review comprehensively examines recent advancements in biochar production, functional modifications, and applications, highlighting the integration of machine learning and artificial ...
Devika Laishram +3 more
wiley +1 more source
Advanced Science, EarlyView.Advanced neoteleost fishbones, such as medaka, challenge bone adaptation strategies. While zebrafish bones contain osteocyte‐mediated porosity, medaka bones lack it, raising questions about alternative reinforcement mechanisms. Using advanced imaging, this study reveals higher residual compressive strains in medaka bone, suggesting an adaptation that ...
Andreia Silveira +7 more
wiley +1 more source