Results 101 to 110 of about 26,419,107 (287)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2006 Due to the broad employment and large amount of electricity consumption of induction motor, their efficient operation has been a focus for engineering research.
Li YF(李延峰), Yu HB(于海斌)
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2016 Condition-based maintenance (CBM) is becoming increasingly important because it performs more efficient diagnoses and prognoses based on equipment condition compared to time-based methods. CBM models greatly inform maintenance decisions.
Lo, Hanna
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
, 2016 In this study, a comparison of equipment maintenance strategies’ cost behaviour is performed under different assumptions regarding equipment failure behaviour, availability of condition monitoring data, and its accuracy.
Farhang Doost, Seyed Alireza
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Distributed embedded condition monitoring management systems based on OSA-CBM standard
, 2013 This paper presents an approach to distributed condition monitoring systems that offers a reusable software architecture for a class of condition monitoring (CM) applications.
Tsourdos, Antonios +2 more
core +1 more source
Applications of artificial intelligence to condition-based maintenance
RAE: Revista de Administração de Empresas, 2000 Os autores discutem aspectos interessantes dos sistemas peritos para diagnóstico de máquina e manutenção baseada em condição de máquina. Nas seções que seguem, os autores examinam alguns elementos de manutenção baseada em condição de máquina e suas ...
Dayr Américo dos Reis, Niranjan Pati
doaj