Results 191 to 200 of about 1,995,749 (291)
Growth type and relative condition factor as a function of the body shape of deep-water crustaceans in the Colombian Caribbean Sea. [PDF]
PeerJParamo J, Rodriguez A, Quintana C.
europepmc +1 more source
Condition Factor Calibration for Load and Resistance Factor Rating of Steel Girder Bridges
, 2016 The Load and Resistance Factor Rating (LRFR) is a reliability-based rating procedure complementary to the Load and Resistance Factor Design (LRFD). The intent of LRFR is to provide consistent reliability for all bridges regardless of in-situ condition ...
Shakya, Pranav M, Shakya, Pranav M.
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Comprehensive systematic review and meta-analysis of microplastic prevalence and abundance in freshwater fish species: the effect of fish species habitat, feeding behavior, and Fulton's condition factor. [PDF]
J Environ Health Sci EngNodehi RN +3 more
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
1645153PDFTech ReportSPR-P1 (16) M043RatingsReliabilityCalibrationGirder bridgesInspectionLoad factorUncertaintySteel girderLRFRcondition factorUnited StatesNebraska Transportation CenterSteelman, JoshuaShakya, PranavUniversity of Nebraska--Lincoln. Dept.
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source