Results 131 to 140 of about 2,975,840 (295)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Condition numbers of Hessenberg companion matrices

Czechoslovak Mathematical Journal
The Fiedler matrices are a large class of companion matrices that include the well-known Frobenius companion matrix. The Fiedler matrices are part of a larger class of companion matrices that can be characterized with a Hessenberg form. In this paper, we demonstrate that the Hessenberg form of the Fiedler companion matrices provides a straight-forward ...
Cox, Michael, Vander Meulen, Kevin N., Van Tuyl, Adam, Voskamp, Joseph   +3 more
openaire   +3 more sources

Initial condition: Number of clusters.

, 2019
Effect of the initial condition on the effective number of clusters (averages over 100 runs).
Alina Sîrbu (112420), Dino Pedreschi (4669261), Fosca Giannotti (4669255), János Kertész (120985)   +3 more
core   +1 more source

A comparative analysis of cylindrical CFS-PML ABC for finite volume simulations in the frequency domain

Journal of Microwaves, Optoelectronics and Electromagnetic Applications, 2014
A comparative analysis of two cylindrical complex-frequency-shifted perfectly matched layers (CFS-PML) absorbing boundary condition (ABC) for bi-dimensional (2-D) finite-volume (FV) simulations in the frequency domain is presented.
Ana Paula M. Lima, Marcela S. Novo
doaj  

Singular-Value-Decomposition-Based Matrix Surgery

Entropy
This paper is motivated by the need to stabilise the impact of deep learning (DL) training for medical image analysis on the conditioning of convolution filters in relation to model overfitting and robustness.
Jehan Ghafuri, Sabah Jassim
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Effective Condition Number for Boundary Knot Method

, 2009
This study makes the first attempt to apply the effective condition number (ECN) to the stability analysis of the boundary knot method (BKM). We find that the ECN is a superior criterion over the traditional condition number.
W. Chen, L. Ling, F.Z. Wang
core   +1 more source