Results 261 to 270 of about 1,028,403 (287)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Individuality across environmental context in <i>Drosophila melanogaster</i>. [PDF]

Elife
Mathejczyk TF, Knief C, Haidar MA, Freitag F, McClary T, Wernet MF, Linneweber GA.   +6 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Neural and Navigational Features Influencing the Novelty Induced Benefits on Episodic Memory. [PDF]

Hippocampus
Vogelsang DA, Calmus CM, Vohs M, Kerkkänen KIL, Hansov S, Schomaker J.   +5 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Mathematical anxiety is associated with general rather than specific weakness in attention. [PDF]

Front Psychol
Ashkenazi S, Danan Y.
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Dissociation of Size and Distance Effect in Numerical Magnitude Comparison in Less Familiar Number Ranges. [PDF]

J Cogn
Garsmeur A, Morand R, Knops A.
europepmc   +1 more source

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Condition Number Theorems in Optimization

SIAM Journal on Optimization, 2003
Summary: Condition numbers for optimization problems in Banach spaces are considered. Lower and upper estimates of the (suitably defined) distance from ill-conditioning are obtained in terms of the reciprocal of condition numbers. An approach is presented based on the metric regularity of the inverse to the arg min map.
openaire   +2 more sources

An Estimate for the Condition Number of a Matrix

SIAM Journal on Numerical Analysis, 1979
It is important in practice when solving linear systems to have an economical method for estimating the condition number $\kappa (A)$ of the matrix of coefficients. An algorithm involving $O(n^2 )$ arithmetic operations is described; it gives a reliable indication of the order of magnitude of $\kappa (A)$.
Cline, A. K., Moler, C. B., Stewart, G. W., Wilkinson, J. H.   +3 more
openaire   +2 more sources