Results 151 to 160 of about 221,779 (297)

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

Clinical Pharmacology &Therapeutics, EarlyView.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra, Viktoriia Starokozhko, Elisabeth Bakker, Anna Maria Gerdina Pasmooij, Peter Gerardus Maria Mol   +4 more
wiley   +1 more source

Deficits in Conditional Discrimination Learning in Children with ADHD are Independent of Delay Aversion and Working Memory. [PDF]

J Clin Med, 2019
Meyer H, Beckers T, Tripp G, van der Oord S.   +3 more
europepmc   +1 more source

Bridging Theory and Prediction: A Hybrid SEM and Machine Learning Approach to Optimize Lean Construction for Megaproject Sustainability in China

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Construction megaprojects, large‐scale, complex, and capital‐intensive, are particularly prone to inefficiencies, cost overruns, delays, and environmental degradation due to fragmented workflows, stakeholder misalignment, and resource intensity.
Abdelazim Ibrahim, Tarek Zayed, Zoubeir Lafhaj, Ahmed Maged, Ahmed Farouk Kineber, Jingchao Yang   +5 more
wiley   +1 more source

Artificial Intelligence as a Catalyst for Environmental and Social Sustainability Practices in SMEs: The Moderating Role of Sustainability, Digitalization, and Innovation Barriers

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study examines the relationship between artificial intelligence and both environmental and social sustainability practices in small and medium‐sized enterprises, with a specific focus on the moderating effects of implementation barriers relating to sustainability, digitalization, and innovation.
Gülçinay Mumcu, Steven A. Brieger
wiley   +1 more source

Active and passive explicit instruction in question‐formulating in higher education

The Curriculum Journal, EarlyView.
Abstract We investigated the impact of explicit instruction on students' question‐formulating skill using a quantitative pre–post design. Surveys were administered to 291 undergraduates from two colleges before and after a dedicated lesson on question formulation. Students' skills were assessed through performance tasks, evaluated with both Bloom's and
Irit Sasson, Sigal Tifferet
wiley   +1 more source

A Comparison of Prompt Delays with Trial-and-Error Instruction in Conditional Discrimination Training. [PDF]

Behav Anal Pract, 2018
O'Neill SJ, McDowell C, Leslie JC.
europepmc   +1 more source

A Discrimination without Previous Conditioning [PDF]

Proceedings of the National Academy of Sciences, 1934
openaire   +2 more sources

Dried biofluid droplet morphologies for automated and scalable disease classification

Droplet, EarlyView.
For the first time, disease‐specific fingerprints of diabetes and influenza are revealed from dried biofluid droplet morphologies. Using automated droplet detection, texture analysis, and interpretable machine learning, this scalable workflow transforms endpoint droplet patterns into diagnostic biomarkers for point‐of‐care healthcare applications ...
Anusuya Pal, Piyush Thakur, Amalesh Gope, Ryuta Uraki, Kawaoka Yoshihiro, Miho Yanagisawa   +5 more
wiley   +1 more source

Evaluating the Effects of Similar and Distinct Discriminative Stimuli During Auditory Conditional Discrimination Training With Children With Autism. [PDF]

Anal Verbal Behav, 2019
Aguirre AA, LeBlanc LA, Reavis A, Shillingsburg AM, Delfs CH, Miltenberger CA, Symer KB.   +6 more
europepmc   +1 more source