Results 31 to 40 of about 399,623 (235)
A Generative Neuro‐Symbolic AI for Protein Sequence Design
Advanced Science, EarlyView.We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne +12 more
wiley +1 more source
, 2011 This thesis sets out to explore divorce law and current reforms. It proposed five themes. Firstly, that no-fault divorce law could be adopted. Secondly, that voluntary mediation may pose several benefits.
VINEY, JOSHUA,WILLIAM
core
Advanced Science, EarlyView.We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen +5 more
wiley +1 more source
Advanced Science, EarlyView.In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen +8 more
wiley +1 more source
The long term effects of legalizing divorce on children [PDF]
We estimate the effect of divorce legalization on the long-term well-being of children. Our identification strategy relies on exploiting the different timing of divorce legalization across European countries. Using European Community Household Panel data,
Tarja Viitanen, Libertad González Luna
core +2 more sources
Advanced Science, EarlyView.The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang +12 more
wiley +1 more source
Advanced Science, EarlyView.NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen +7 more
wiley +1 more source
The impact of divorce on anxiety in elementary-aged children [PDF]
, 2003 Plan BThe purpose of this critical analysis of the literature was to determine the impact of divorce on levels of anxiety in elementary-aged children. The literature review also sought to determine what types of intervention strategies are available for ...
Jasinski, Faith
core
Advanced Science, EarlyView.Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh +22 more
wiley +1 more source
The Extended Conditional Statement in the Islamic Jurisprudence
دراسات: علوم الشريعة والقانون, 2020 This research reflects the method of the Extended Conditional Statement in the Islamic Jurisprudence, where it reveals the meaning of the interception of the condition to the condition, in an obvious sense: the correlation of the occurrence of result ...
Osama Adnan Eid ALghonmeen
doaj