Results 101 to 110 of about 692,083 (345)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

Examining the Relationship between Diversification of Banking Resources and Expenses and Systemic Risk [PDF]

open access: yesراهبرد مدیریت مالی
The purpose of this article was to investigate the relationship between the diversification of banking resources and expenses with systemic risk in the country's banking system.
Yazdan Gudarzi Farahani   +2 more
doaj   +1 more source

Single‐Field Evolution Rule Governs the Dynamics of Representational Drift in Mouse Hippocampal Dorsal CA1 Region

open access: yesAdvanced Science, EarlyView.
Long‐term hippocampal place‐code dynamics are investigated using calcium imaging across weeks of maze navigation. Analyses reveal a novelty‐irrelevant Single‐Field Evolution Rule (SFER), where active fields promote persistence and inactive fields decline.
Cong Chen   +10 more
wiley   +1 more source

Hedging Risks in the Loss-Averse Newsvendor Problem with Backlogging

open access: yesMathematics, 2019
This paper studies the optimal order decisions for the loss-averse newsvendor problem with backordering and contributes to the risk hedging issue in the newsvendor model.
Xiaoqing Liu   +2 more
doaj   +1 more source

Beyond Value at Risk (VaR): The Conditional VaR (CvaR) [PDF]

open access: yes, 2007
En los últimos años, el Valor en Riesgo (VeR) se ha convertido en un patrón comúnmente utilizado en la medición del Riesgo de Mercado por los directivos bancarios.
Feria Domínguez, José Manuel   +1 more
core  

Western Diet Inhibits FUT7‐Mediated Treg Intestinal Homing to Disrupt the Homeostasis of Intestinal Epithelial Cells in Crohn's Disease

open access: yesAdvanced Science, EarlyView.
In this study, we constructed a nanoparticle that was CD4 antibody‐mediated targeted, Fut7‐expressing plasmid‐loaded cationic liposome, namely CD4‐LDP‐Fut7. Upregulation of Fut7 expression in Tregs by using CD4‐LDP‐Fut7 can increase Treg homing to the intestine, thereby facilitating repair of the intestinal epithelial barrier and inhibiting ...
Qian Zhou   +13 more
wiley   +1 more source

Risk Management of Precious Metals [PDF]

open access: yes
This paper examines volatility and correlation dynamics in price returns of gold, silver, platinum and palladium, and explores the corresponding risk management implications for market risk and hedging. Value-at-Risk (VaR) is used to analyze the downside
Farooq Malik   +2 more
core   +3 more sources

Trading risk control model of electricity retailers in multi‐level power market of China

open access: yesEnergy Science & Engineering, 2019
The decision‐making and risk assessment of electricity purchase and sales is the key to adapt to the electricity market for independent electricity retailers in China.
Xiaobao Yu, Yixin Sun
doaj   +1 more source

CVaR sensitivity with respect to tail thickness [PDF]

open access: yes
We consider the sensitivity of conditional value-at-risk (CVaR) with respect to the tail index assuming regularly varying tails and exponential and faster-than-exponential tail decay for the return distribution. We compare it to the CVaR sensitivity with
Fabozzi, Frank J.   +2 more
core  

Home - About - Disclaimer - Privacy