Results 41 to 50 of about 3,593 (265)
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Conditionality in the Equestrian World: A Preliminary Approach
International Journal of Equine ScienceThe theory of conditionality originates from the field of social thinking, specifically from the study of normative aspects that are considered conditional. It examines legitimate transgressions and has numerous applications, particularly in road safety.
Sandrine Gaymard, Florian Beucher
doaj +1 more source
SETBACKS AND ACHIEVEMENTS IN MANAGING THE EASTERN NEIGHBOURHOOD [PDF]
CES Working Papers, 2013 Since its latest enlargements, the European Union has constantly developed various actions and initiatives in order to secure its borders and consequently to be surrounded by countries with dynamic economies and secure and stable political situations. So
Loredana Maria Simionov
doaj
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane +43 more
wiley +1 more source
EUROPEAN COMPLIANCE AND POLITICIZATION OF PUBLIC ADMINISTRATION IN ROMANIA [PDF]
Innovative Issues and Approaches in Social Sciences, 2013 This paper addresses the problem of public administration politicization in Romania between 1990 and 2012. The approach taken here is that of Europeanization by conditionality and social learning, and of reform reversal hypothesis where the social ...
Diana - Camelia Iancu
doaj
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Politics and Governance, 2023 This article examines the main features of the Recovery and Resilience Plans (RRPs) that member states have presented to access NextGenerationEU (NGEU) funds, and it explores the relationship between NGEU and the European Semester.
Mattia Guidi +2 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes +75 more
wiley +1 more source
SSRN Electronic Journal, 2023 Over the last decade, the European Union's (EU) rule of law instruments have grown exponentially. This development was commensurable to the rule of law challenges that the EU faced within the Member States – Hungary and Poland being the main perpetrators. However, more instruments have not led to better results.
openaire +2 more sources
Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif +17 more
wiley +1 more source