Results 41 to 50 of about 2,129 (259)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Actuality and fake tense in conditionals
Semantics and Pragmatics, 2015 Sabine Iatridou (2000) and Katrin Schulz (2014) defend accounts of the past tense in subjunctive conditionals according to which the past tense has a modal reading that excludes the world of utterance or some set of epistemically possible worlds. I argue
John Mackay
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Frontiers in Psychology, 2019 Three experiments tracked participants’ eye-movements to examine the time course of comprehension of the dual meaning of counterfactuals, such as “if there had been oranges then there would have been pears.” Participants listened to conditionals while ...
Isabel Orenes +4 more
doaj +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Reports on Mathematical Logic, 2018 In this paper we isolate a property for forcing notions, the *-Prikry condition, that is similar to the Prikry condition but that is topological: A forcing P satisfies it iff for every p ∈ P and for every open dense D ⊆ P, there are n ∈ ω and q ≤∗ p such that for any r ≤ q with l(r) = l(q) + n, r ∈ D, for some length notion l.
openaire +2 more sources
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
MODUS PONENS AND MODUS TOLLENS: THEIR VALIDITY/INVALIDITY IN NATURAL LANGUAGE ARGUMENTS
Studies in Logic, Grammar and Rhetoric, 2017 The precedent studies on the validity of Modus ponens and Modus tollens have been carried out with most regard to a major type of conditionals in which the conditional clause is a sufficient condition for the main clause.
Ri Yong-Sok
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane +43 more
wiley +1 more source