Results 51 to 60 of about 39,994 (297)

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Asymmetries in the Acceptability and Felicity of English Negative Dependencies: Where Negative Concord and Negative Polarity (Do Not) Overlap

open access: yesFrontiers in Psychology, 2019
Negative Concord (NC) constructions such as the news anchor didn’t warn nobody about the floods (meaning “the news anchor warned nobody”), in which two syntactic negations contribute a single semantic one, are stigmatized in English, while their Negative
Frances Blanchette, Cynthia Lukyanenko
doaj   +1 more source

Presupposing Counterfactuality [PDF]

open access: yes, 2019
There is long standing agreement both among philosophers and linguists that the term ‘counterfactual conditional’ is misleading if not a misnomer. Speakers of both non-past subjunctive (or ‘would’) conditionals and past subjunctive (or ‘would have ...
Zakkou, Julia
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Evaluability: an alternative approach to polarity sensitivity [PDF]

open access: yes, 2013
Based on Brandtler (2012), this paper argues that polarity items are sensitive to evaluability, a concept that refers to the possibility of accepting or rejecting an utterance as true in a communicative exchange.
Brandtler, Johan
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

'Should conditionals be emergent ...': asyndetic conditionals in English and German as a Challenge to Grammaticalization Research [PDF]

open access: yes, 2010
The present article examines asyndetic or conjunctionless conditionals in German and English. According to Jespersen’s Model (1940), this construction arose diachronically from a paratactic discourse sequence with a polar interrogative, but more recently
Van den Nest, Daan
core   +1 more source

Conditional extremals

open access: yesMathematics of Control, Signals, and Systems, 2012
25 pages, 8 ...
openaire   +2 more sources

Conditional and Conditioned Reasons

open access: yesUtilitas, 2002
This paper is a brief reponse to some of Douglas Portmore's criticisms of our version of the agent-relative/agent-neutral distinction.In his interesting and helpful paper ‘McNaughton and Rawling on the Agent-relative/Agent-neutral Distinction’, Douglas Portmore criticizes our formalization of duties on the grounds that we have over-looked an important ...
David McNaughton, Piers Rawling
openaire   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron   +5 more
wiley   +1 more source

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