Results 51 to 60 of about 57,174 (290)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Enhancing the Effects of Neurofeedback Training: The Motivational Value of the Reinforcers

open access: yesBrain Sciences, 2021
The brain activity that is measured by electroencephalography (EEG) can be modified through operant conditioning, specifically using neurofeedback (NF).
Rubén Pérez-Elvira   +10 more
doaj   +1 more source

Mushroom-bodies mediate hierarchical interactions between fact- and skill-learning in _Drosophila_ [PDF]

open access: yes, 2007
Different brain circuits mediate the acquisition of skills and habits (via operant/instrumental learning) and the acquisition of facts (via classical/Pavlovian learning).
Bjö, Wolfgang Plendl
core  

Expanding the boundaries of evaluative learning research: how intersecting regularities shape our likes and dislikes [PDF]

open access: yes, 2016
Over the last 30 years, researchers have identified several types of procedures through which novel preferences may be formed and existing ones altered. For instance, regularities in the presence of a single stimulus (as in the case of mere exposure) or ...
De Houwer, Jan   +2 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Operant conditioning of stochastic chemical reaction networks.

open access: yesPLoS Computational Biology, 2022
Adapting one's behavior to environmental conditions and past experience is a key trait of living systems. In the biological world, there is evidence for adaptive behaviors such as learning even in naturally occurring, non-neural, single-celled organisms.
David Arredondo, Matthew R Lakin
doaj   +1 more source

Conditional Probability Operators

open access: yesThe Annals of Mathematical Statistics, 1962
The study of laws of random variables is facilitated by various methods of representing these laws. The distribution function and characteristic function have played an important role, and the functional representation of the law of a random variable $X$ as a mapping $T$ of the bounded Borel functions into the real line given by $Tg = Eg(X)$ connects ...
openaire   +3 more sources

Quantum Probability and Operant Conditioning: Behavioral Uncertainty in Reinforcement Learning [PDF]

open access: yes, 2014
An implicit assumption in the study of operant conditioning and reinforcement learning is that behavior is stochastic, in that it depends on the probability that an outcome follows a response and on how the presence or absence of the output affects the ...
Alonso, E., Mondragon, E.
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

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