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Side Effects of Conditioning Regimens
1992Despite the reconstitutive effects of marrow transplantation on hematopoiesis, severe hematologic and non-hematologic toxicity is produced by the myeloablative conditioning regimens commonly used to condition patients. Specific toxicities depend on the agents employed, their dose and schedule as well as the patient’s overall clinical condition, co ...
H. Joachim Deeg +2 more
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Conditioning regimens for allogeneic bone marrow transplantation
Blood Reviews, 1992Conditioning regimens for transplantation are important in determining transplant outcome. This review focuses on transplantation in aplastic anemia and leukemia using marrow from HLA-identical siblings. Results of conditioning with newer regimens such as busulfan plus cyclophosphamide and etoposide plus total body irradiation are reviewed and compared
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Novel conditioning and prophylaxis regimens for relapse prevention
HematologyAbstract The last 20 years witnessed relevant clinical advancements in the field of hematopoietic cell transplantation (HCT) for leukemia patients. The introduction of novel conditioning regimens, a better prophylaxis and management of graft- versus-host disease, and an ameliorated posttransplant support system improved safety and ...
Antonella, Mancusi +2 more
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Conditioning regimens: balancing efficacy and toxicity
Leukemia & Lymphoma, 2023Taylor R, Brooks, Deepa, Jagadeesh
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Conditioning regimens for allogeneic stem cell transplants
Current Opinion in Hematology, 2000In addition to providing cytoreduction at myeloablative dose intensity, conditioning regimens for allogeneic transplantation are designed to immunosuppress the recipient to permit donor lymphohematopoietic engraftment and thereby establish a graft-versus-malignancy effect.
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Toxicity of Conditioning Regimens in Haploidentical SCT
2017The intensity of the conditioning regimens whether myeloablative or non myeloablative are as the same as they are in the full match allogeneic transplantations and even, the drugs are the same for both transplantation types. The advances in the haploidentical HSCT is mostly the result of the usage of post transplantation cyclophosphamide (PT-CY) as ...
Meltem Kurt Yüksel, Taner Demirer
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Conditioning regimens in bone marrow transplantation
1991The ideal conditioning regimen for marrow transplants both destroys the underlying malignant disease and abrogates host immunity sufficiently to prevent rejection of the graft without undue toxicity. Unfortunately, such a regimen does not exist. A commonly used regimen in Seattle includes the immunosuppressive and anticancer drug cyclophosphamide (CY),
R. Storb +12 more
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Conditioning Regimens for Cord Blood Transplantation
2017Conditioning regimens prior to allogeneic hematopoietic cell transplantation (allo-HCT) serve to suppress the patient’s immune system to allow infused progenitor and stem cells to engraft and, in the case of malignant diseases, to target residual disease to reduce relapse risk.
Kelly Ross, Jonathan Gutman
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The role of TBI in conditioning regimens for children.
Bone marrow transplantation, 1991TBI is currently used as a conditioning regimen in bone marrow transplantation (BMT) with various Radiation doses, fractionation scheduling and dose rate. In children, the most frequent neoplasms treated with TBI are leukemias and advanced Neuroblastoma (NB). In leukemias the radiation dose plays an important role, particularly in patients at high risk
V, Vitale, P, Franzone
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