Results 101 to 110 of about 772,904 (264)
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
Developing and Piloting Suicide Prevention Training in Pediatric Primary Care
JAACAP OpenObjective: Suicide prevention is an expected competency of pediatric primary care clinicians (PPCCs). Suicide prevention training should be tailored to the recipient’s setting, localized needs, and available models of care. This article describes a first
John T. Parkhurst, PhD +7 more
doaj +1 more source
Safeguarding in schools : best practice [PDF]
, 2011 "This report illustrates and evaluates the features of best practice in safeguarding, based on inspection evidence from the 19% of all maintained primary, secondary and special schools, residential special schools and pupil referral units inspected ...
core
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Distributed Learning System Design: A New Approach and an Agenda for Future Research [PDF]
, 2006 This article presents a theoretical framework designed to guide distributed learning design, with the goal of enhancing the effectiveness of distributed learning systems.
Bell, Bradford S. +1 more
core +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
Reassessment of aviation risk safety barriers using stochastic and lexical uncertainty
Scientific ReportsResults of many investigations and statistical data indicate that aircraft accidents are an iceberg phenomenon for understanding the gap among traffic management, operations, and aviation systems.
Hendri Saputra, Sutanto Soehodho
doaj +1 more source
Journal of Research in Education Sciences面對世界變革及教育系統之需求，本研究重新從認識論與方法論建立課程評鑑之基礎，並擴大視野，跨越邊界，透過朝向問題化的設計思考，規劃能喚起個體在群體中及對系統的覺知，反思課程實踐，建立具價值與意義之課程評鑑引導設計。本研究主要運用團體討論法，經過8次，每次1-2小時的團體討論，進行「意義驅動與展化的課程評鑑工作坊」之引導設計， 並以關鍵字分析和提問類型進行資料分析，再以參與工作坊學員之意見調查與備課文件作為語料分析之佐證。本研究發現包括：一、融入展化學習及U型理論之問題化的設計思考可生成課程新的理解；二 ...
陳美如 Mei-Ju Chen +4 more
doaj +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source