Results 121 to 130 of about 148,827 (308)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

The effects of crosslinking byproducts on the electrical properties of low density polyethylene

, 2011
Crosslinked polyethylene (XLPE) is widely used for high voltage insulation in power transmission systems. However, it has been found that, after crosslinking with Dicumyl Peroxide (DCP), the crosslinking byproducts such as acetophenone, ?-methylstyrene ...
Hussin, Nuriziani
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Effect of Gradient Heat Conduction on Secondary Recrystallization of Grain-Oriented Silicon Steel

Metals
The grain-oriented silicon steels were subjected to gradient heat conduction during high-temperature annealing by using thermal insulation cotton. The macrostructures of samples subjected to circumferential gradient heat conduction showed a “petal-like ...
Qian Gao, Xianhui Wang, Jun Li, Laifu Cao, Jian Gong, Bo Li   +5 more
doaj   +1 more source

Retificador PFC monofásico PWM bridgeless três-níveis de alto desempenho [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia ElétricaEste trabalho apresenta uma nova topologia de retificador monofásico com fator de potência e rendimento elevados, com o ...
Lange, André De Bastiani
core  

Unilateral and Bilateral Audiological Benefit With an Adhesively Attached, Noninvasive Bone Conduction Hearing System.

, 2018
OBJECTIVE To assess the audiological benefit of a noninvasive, adhesively attached bone conduction device (BCD1) in subjects with induced bilateral conductive hearing loss.
Munzinger, Fabio, Wilhelm Wimmer, Gawliczek, Tom, Anschütz, Lukas Peter, Fabio Munzinger, Kompis, Martin, Caversaccio, Marco, Marco Caversaccio, Lukas Anschuetz, Martin Kompis, Wimmer, Wilhelm, Tom Gawliczek   +11 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Evaluation of Cochlear Function in safe type of Chronic Otitis Media

Bengal Journal of Otolaryngology and Head Neck Surgery, 2013
Objective of this article is to evaluate the correlation between the patients of safe types of chronic otitis media (COM) with their cochlear function of sensorineural hearing loss (SNHL).
Debasis Barman, Manotosh Dutta, Manoj Mukherjee, Asim Sarkar, Santanu Shit, Apurba Sarkar   +5 more
doaj  

PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates

Life Science Alliance
PRDM16 loss in cardiomyocytes during development causes an atrial and conduction fate shift and distal ventricular conduction system hyperplasia resulting in premature death or cardiac dysfunction.
Jore Van Wauwe, Alexia Mahy, Sander Craps, Samaneh Ekhteraei-Tousi, Pieter Vrancaert, Hannelore Kemps, Wouter Dheedene, Rosa Doñate Puertas, Sander Trenson, H. Llewelyn Roderick, Manu Beerens, Aernout Luttun   +11 more
doaj   +1 more source