Results 111 to 120 of about 148,827 (308)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Coordinated Tbx3/Tbx5 transcriptional control of the adult ventricular conduction system
eLifeThe cardiac conduction system (CCS) orchestrates the electrical impulses that enable coordinated contraction of the cardiac chambers. The T-box transcription factors TBX3 and TBX5 are required for CCS development and associated with overlapping and ...
Ozanna Burnicka-Turek +12 more
doaj +1 more source
Mechanisms of Bone Conduction: A Review of the Literature
, 2021 Clinical bone conduction during a routine audiological evaluation is a vital tool for audiologists to differentiate a sensorineural hearing loss from a conductive hearing loss.
Soslowsky, Samara Miranda
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Wide Range ZVS Phase Shift Full Bridge Converter with Low Conduction Loss
, 2011 The conventional phase shift full bridge (PSFB) converter is widely used for front-end DC/DC stage of distributed power system (DPS). However, hold-up time requirement limits its operating duty ratio in normal operation and it results in the increase of ...
Moon, GunWoo +5 more
core
Electron energy loss spectroscopy of single silicon nanocrystals: The conduction band [PDF]
, 1993 Spatially resolved electron energy loss spectroscopy has been performed on single, H-terminated, Si nanocrystals in the size range 25–500 Å. The particles were prepared via the gas-phase photolysis of a dilute Si2H6/He mixture in a gas flow cell, and ...
Batson, P. E., Heath, J. R.
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
The contribution of brain reorganisation to recovery in patients with optic neuritis
, 2010 In this thesis, the mechanisms of damage and repair in clinically isolated optic neuritis (ON) were investigated in vivo, by combining magnetic resonance imaging (MRI), electrophysiology and optical coherence tomography (OCT).
Jenkins, T.M.
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Assessing the Production and Loss of Electrons from Conduction Currents in Mineral Oil
, 2019 The evaluation of the high-field generation and loss of charged carriers is a key step to simulate any prebreakdown process in a dielectric liquid. Currently, the electron generation in mineral oil has been widely described in terms of 'electric-field ...
Aljure, Mauricio, +5 more
core +1 more source