Results 51 to 60 of about 2,933 (260)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

High throughput quantification of battery solid electrolyte interphase conductivities and their use as solid state electrolytes [PDF]

open access: yes, 2023
As a key passivation layer that governs battery operation, the solid electrolyte interphase (SEI) has long been credited for enabling high performing batteries or blamed for their eventual death.
Chen, Po-Hung
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Design and analysis of wireless charging combined with conductive charging

open access: yes, 2017
One way to reduce the amount of emissions from vehicles is to replace the combustion cars with electrical vehicles. To encourage people to do this the electrical vehicles needs to be improved but also the way of charging them.
Berntsson, Viktor
core  

Electron energy relaxation under terahertz excitation in (Cd1−xZnx)3As2 Dirac semimetals

open access: yes, 2020
We demonstrate that measurements of the photo-electromagnetic effect using terahertz laser radiation provide an argument for the existence of highly conductive surface electron states with a spin texture in Dirac semimetals (Cd₁-xZnx ...
Drozdov, K. A.   +4 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Arguing Conductively or Arguing Strategically?

open access: yes, 2015
Conference Papers and Commentary.The topic of conductive argument has attracted much attention in recent argumentation studies, but most of the existing discussions are centered on a logical or epistemological perspective.
Xie, Yun
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Independence of the sodium and potassium conductance channels. A kinetic argument.

open access: yesBiophysical journal, 1971
Tightly coupled models for the sodium and potassium conductance changes, in which the potassium "on" process is intimately related to the sodium "on" and "off" processes, are studied. It is shown that such coupled models are incapable of simultaneously showing the observed effects of conditioning potentials on sodium inactivation and on the translation
openaire   +2 more sources

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