Results 61 to 70 of about 2,933 (260)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Conductivismo, o pro y contras de considerar todo argumento como conductivo
, 2020 Deductivism is the privileging of the deductive model in argumentation studies. In this paper I propose, as an alternative account, conductivism: the privileging of the conductive model. First, I analyze and discuss the deductivist approach.
Vilanova, Javier
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
What's the coincidence in debunking? [PDF]
, 2022 Many moral debunking arguments are driven by the idea that the correlation between our moral beliefs and the moral truths is a big coincidence, given a robustly realist conception of morality.One influential response is that the correlation is not a ...
Bhogal, Harjit
core
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hemivariational inequalities modeling electro-elastic unilateral frictional contact problem
, 2017 We study a class of abstract hemivariational inequalities in a reflexive Banach space. For this class, using the theory of multivalued pseudomonotone mappings and a fixed-point argument, we provide a result on the existence and uniqueness of the ...
Gamorski, Piotr +3 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
A critical analysis of the effects of tourism on cultural representation: a case study from Leboeng [PDF]
, 2004 Magister Artium - MA (Anthropology/Sociology)Cultural tourism is a vehicle for economic growth. Cultural representations are made in order to make the cultural tourism sector a more vibrant one.
Mamadi, Masete
core +1 more source
, 2020 This paper intervenes in the Granovetter-Polanyi debate by reassessing the level of embeddedness of social and economic relations under conditions of systemic transition.
Wilk, Katarzyna
core