Results 61 to 70 of about 2,111 (257)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Raman study of insulating and conductive ZnO: (Al, Mn) thin films

, 2015
Raman spectroscopy results obtained for undoped and Al- and/or Mn-doped ZnO thin films produced by RF-sputtering are reported. The effect of the doping method (either co-sputtering or ion implantation), the dopant type and its concentration on the Raman ...
Cerqueira, M. F., Lacerda-Arôso, T. de, Vasilevskiy, Mikhail, Campos, J. Ayres de, Alves, E., Viseu, T. M. R., Bogdanovic-Radovic, I., Oliveira, F., Rolo, Anabela G.   +8 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Analysis of a Signorini problem with nonlocal friction in thermo-piezoelectricity

, 2016
We consider a mathematical model which describes the frictional unilateral contact between a thermo-piezoelectric body and a rigid electrically conductive foundation. The thermo-piezoelectric constitutive law is assumed to be nonlinear and the contact is
Fakhar, R., EL-H. Essoufi, R. Fakhar, H. Benaissa, Benaissa, H., Essoufi, EL-H.   +5 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Arguments for and against the allowance of a global one-child policy - an assessment of our right to children and our future prospects

, 2018
I dette speciale undersøger jeg vores ret til børn for at identificere og evaluere centrale argumenter for og imod tilladeligheden af indførslen af en global etbarnspolitk.
Christensen, Sara Tolstrup
core  

Analysis of an Antiplane Contact Problem with Adhesion for Electro-Viscoelastic Materials

, 2008
We consider a mathematical model which describes the antiplane shear deformation of a cylinder in frictionless contact with a rigid foundation. The adhesion of the contact surfaces, caused by the glue, is taken into account.
Selmani, L., Chouchane, L., Sofonea, M.
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source