Results 1 to 10 of about 5,675 (134)
Recent Insights in Multi-Target Drugs in Pharmacology and Medicinal Chemistry. [PDF]
ChemMedChemThis review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Cemali SH +7 more
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Gene Expression, Docking and Machine Learning in Malaria Drug Discovery: A Systematic Review. [PDF]
Biochem Res IntBackground Malaria remains a significant and worldwide health threat with increasing resistance to current treatments, stimulating the demand for innovative approaches in pursuing drug discovery. This systematic review integrates the progress made from 2014 through 2024 regarding molecular methods like gene expression profiling, molecular docking and ...
Dangana RS +4 more
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Long non-coding RNAs as key regulators of neurodegenerative protein aggregation. [PDF]
Alzheimers DementAbstract The characteristic events in neurodegenerative diseases (NDDs) encompass protein misfolding, aggregation, accumulation, and their related cellular dysfunction, synaptic function loss. While distinct proteins are implicated in the pathological processes of different NDDs, the process of protein misfolding and aggregation remains notably similar
Xu Q, Liu D, Zhu LQ, Su Y, Huang HZ.
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Dendritic Cell Migration: An Essential Step in Initiating Adaptive Immunity Across Tissues. [PDF]
Immunol RevABSTRACT Immune surveillance of tissues is primarily carried out by dendritic cells (DCs), which act as sentinels for the adaptive immune system. To accomplish this task, DCs migrate from tissues to regional lymph nodes, or from blood‐exposed regions of the spleen to the white pulp, to prime T cell responses. DC migration is a tightly regulated process
Olson EC, Williams A, Eisenbarth SC.
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A Case Study of Contextual and Emotional Modulation of Source-case Selection in Analogical Arguments
Informal Logic, 2023 In making analogical arguments about actions, is more similarity between the source and target cases always better? No: all things considered, more similarity is not always better, even if the similarities are all relevant.
Marcello Guarini
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Fuzzy Sub-Equality Algebras Based on Fuzzy Points
Bulletin of the Section of Logic, 2023 In this paper, by using the notion of fuzzy points and equality algebras, the notions of fuzzy point equality algebra, equality-subalgebra, and ideal were established. Some characterizations of fuzzy subalgebras were provided by using such concepts.
Mona Aaly Kologani +3 more
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Cut Elimination for Extended Sequent Calculi
Bulletin of the Section of Logic, 2023 We present a syntactical cut-elimination proof for an extended sequent calculus covering the classical modal logics in the \(\mathsf{K}\), \(\mathsf{D}\), \(\mathsf{T}\), \(\mathsf{K4}\), \(\mathsf{D4}\) and \(\mathsf{S4}\) spectrum.
Simone Martini +2 more
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Auditory Arguments: The Logic of 'Sound' Arguments
Informal Logic, 2018 This article discusses “auditory” arguments: arguments in which non-verbal sounds play a central role. It provides examples and explores the use of sounds in argument and argumentation.
Leo Groarke
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Deep Disagreement and the Virtues of Argumentative and Epistemic Incapacity
Informal Logic, 2018 Fogelin’s (1985) Wittgensteinian view of deep disagreement as allowing no rational resolution has been criticized from both argumentation theoretic and epistemological perspectives. These criticisms typically do not recognize how his point applies to the
Jeremy Barris
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Knowing when Disagreements are Deep
Informal Logic, 2005 Reasoned disagreement is a pervasive feature of public life, and the persistence of disagreement is sometimes troublesome, reflecting the need to make difficult decisions.
David M. Adams
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