Results 21 to 30 of about 5,616 (132)

Transcriptional Regulation of Microglial Metabolic and Activation States by P2RY12

Glia, Volume 73, Issue 12, Page 2464-2482, December 2025.
Main Points Transcriptionally, P2RY12‐deficient microglia show heightened metabolic activity, iron handling and oxidative stress at baseline. Upon LPS challenge, impaired glutathione antioxidant responses suggest increased vulnerability to ferroptosis. ABSTRACT Microglia are the resident immune cells of the CNS.
Aida Oryza Lopez‐Ortiz, Madison Doceti, JaQuinta Thomas, Abigayle Duffy, Morgan Coburn, Akhabue K. Okojie, Audrey Lee, Elizabeth Aidita Sou, Alban Gaultier, Ukpong B. Eyo   +9 more
wiley   +1 more source

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

Cell Proliferation, Volume 58, Issue 11, November 2025.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far, Marziyeh Akbari, Mohammad Amin Habibi, Morteza Katavand, Sherko Nasseri   +4 more
wiley   +1 more source

Innovative Wirkstoffe aus der antibakteriellen Forschung im Kampf gegen mikrobielle Resistenzen

Angewandte Chemie, Volume 137, Issue 10, March 3, 2025.
Dieser Artikel gewährt einen Überblick über in den letzten drei Jahrzehnten untersuchte antibakteriellen Wirkstoffe. Aspekte der Herkunft, der zellulären Targetstrukturen, des antibakteriellen Wirkspektrums und dem Nachweis der Wirksamkeit in Tierstudien werden zusammen mit aktuellen Entwicklungen beleuchtet.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source

Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research

Angewandte Chemie International Edition, Volume 64, Issue 10, March 3, 2025.
This article provides an overview over antibacterial drugs investigated in the past three decades. Aspects of the compound's origins, their cellular targets, the antibacterial spectrum and proof‐of‐concept in animal studies are covered and current trends are highlighted.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source

All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants

Advanced Science, Volume 12, Issue 5, February 3, 2025.
Crops lost to diseases necessitate a deeper understanding of plant immunity and the development of disease resistance. Here, the arms‐race between plants and pathogens is briefly described, and a comprehensive overview of the current and emerging strategies for engineering disease resistance in plants is provided.
Aziz Ul Ikram, Muhammad Saad Shoaib Khan, Faisal Islam, Sulaiman Ahmed, Tengfang Ling, Feng Feng, Zongtao Sun, Huan Chen, Jian Chen   +8 more
wiley   +1 more source

The Rationality of Legal Discourse in Habermas's Discourse Theory

Informal Logic, 2003
This paper argues that Habermas's conception of the rationality of moral and legal discussions has import for argumentation theorists interested in the rationality of public deliberations in politics and law.
Eveline T. Feteris
doaj   +1 more source

A Searchable Bibliography of Fallacies – 2016

Informal Logic, 2016
This bibliography of literature on the fallacies is intended to be a resource for argumentation theorists. It incorporates and sup- plements the material in the bibliography in Hansen and Pinto’s Fallacies: Classical and Contemporary Readings (1995), and
Hans V. Hansen, Cameron Fioret
doaj   +1 more source

Challenges to the ancient methane seep search strategy: The Bedford Canyon Formation (Middle Jurassic, Santa Ana Mountains, California)

Sedimentology, Volume 72, Issue 2, Page 688-707, February 2025.
Abstract Carbonates formed by anaerobic oxidation of methane at localized seeps have been recognized in the rock record based on a list of criteria, including anomalous deposition within detrital facies, complex petrofabrics, seep‐endemic macrofauna and 13C‐depleted isotopic signatures.
Russell S. Shapiro, Miquela Ingalls
wiley   +1 more source

Clinical Validity of the Nursing Diagnoses Impaired Gas Exchange (00030) and Ineffective Breathing Pattern (00032) in Post‐COVID‐19 Individuals

Nursing Forum, Volume 2025, Issue 1, 2025.
Purpose: To examine the clinical construct validity and specific causal validity of the nursing diagnoses of impaired gas exchange (00030) and ineffective breathing pattern (00032) in post‐COVID‐19 individuals. Methods: A correlational and cross‐sectional study was conducted. A total sample of 199 individuals with a previous COVID‐19 diagnosis, aged 18 
Noemí González-Falcón, Aylin Guadalupe Pérez-Pérez, Nathalie Lynette Aguilar-Escamilla, Gabriela Maldonado-Muñiz, Claudia Atala Trejo-García, Paula Escalada-Hernández, José Manuel Romero Sánchez   +6 more
wiley   +1 more source

Empirical Negation, Co-Negation and the Contraposition Rule II: Proof-Theoretical Investigations

Bulletin of the Section of Logic, 2020
We continue the investigation of the first paper where we studied logics with various negations including empirical negation and co-negation. We established how such logics can be treated uniformly with R. Sylvan's CCω as the basis.
Satoru Niki
doaj   +1 more source