Results 11 to 20 of about 21,046,637 (158)
Recent Insights in Multi-Target Drugs in Pharmacology and Medicinal Chemistry. [PDF]
This review highlights the rationale behind multitarget drug design as a promising approach to address diseases with complex etiologies. By combining pharmacophore features from different single‐target drugs, multitarget compounds can interact with multiple biological targets simultaneously.
Cemali SH +7 more
europepmc +2 more sources
Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report. [PDF]
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Roth-Walter F +19 more
europepmc +2 more sources
Gene Expression, Docking and Machine Learning in Malaria Drug Discovery: A Systematic Review. [PDF]
Background Malaria remains a significant and worldwide health threat with increasing resistance to current treatments, stimulating the demand for innovative approaches in pursuing drug discovery. This systematic review integrates the progress made from 2014 through 2024 regarding molecular methods like gene expression profiling, molecular docking and ...
Dangana RS +4 more
europepmc +2 more sources
Long non-coding RNAs as key regulators of neurodegenerative protein aggregation. [PDF]
Abstract The characteristic events in neurodegenerative diseases (NDDs) encompass protein misfolding, aggregation, accumulation, and their related cellular dysfunction, synaptic function loss. While distinct proteins are implicated in the pathological processes of different NDDs, the process of protein misfolding and aggregation remains notably similar
Xu Q, Liu D, Zhu LQ, Su Y, Huang HZ.
europepmc +2 more sources
Recent Developments in Compatibilization Strategies for Polymer Blends and Nanocomposites
This review highlights recent developments and emerging compatibilization strategies in polymer blends and polymer nanocomposites. Importance of compatibilization in polymer nanocomposites is discussed, and physical methods are compared with chemical methods.
Minoo Ahmadi +3 more
wiley +1 more source
Abstract Studying the combining ability of pro‐vitamin A enriched yellow maize inbred lines (Zea mays L.) provides valuable information on the breeding potential of these lines for developing high‐yielding and biofortified maize hybrids with desirable agronomic traits.
Belay Garoma +3 more
wiley +1 more source
The Thomas-Nolt Dispute: Some Lessons about Induction
I resolve an apparently unresolved dispute about how probable uniform experience makes an extrapolation from it, and draw some general lessons about such enumerative induction.
David Hitchcock
doaj +1 more source
The orthoquinone metabolites from plants have antimicrobial, antioxidant, antiviral, cytotoxic, and anti‐inflammatory effects. ABSTRACT The structural diversity of natural products is vast and fascinating, and they have been recognized as an enormously diverse source of new lead compounds.
Hidayat Hussain +5 more
wiley +1 more source
Analytical Frameworks and Theories of Electric Power in Non‐Linear Circuits
Based on the challenges of distorted currents and non‐linear components in modern power grids, this article reviews seminal electrical power theories that seek to generalize the traditional definitions of active, reactive, and apparent power. It provides a detailed analysis of their mathematical foundations, practical implementation, and validity.
Rafael Escudero, Luis Ibarra
wiley +1 more source

