Results 101 to 110 of about 42,890 (207)

Structural diversity of neuronal calcium sensor proteins and insights for activation of retinal guanylyl cyclase by GCAP1. [PDF]

, 2014
Neuronal calcium sensor (NCS) proteins, a sub-branch of the calmodulin superfamily, are expressed in the brain and retina where they transduce calcium signals and are genetically linked to degenerative diseases.
Ames, James B, Dizhoor, Alexander M, Lim, Sunghyuk   +2 more
core   +2 more sources

Waveguide Properties of Cone Photoreceptors

Frontiers in Optics 2015, 2015
Photoreceptors waveguide light, but the extent to which they do remains controversial. We provide new insight into the complexity of this process using AO-OCT to isolate reflections that originate in the inner and outer ...
openaire   +2 more sources

Light reflectivity and interference in cone photoreceptors

Biomedical Optics Express, 2019
In several modes of retinal imaging, the primary means of visualizing cone photoreceptors is from reflected light. Understanding how such images are formed, particularly when adaptive optics techniques are used, will help to guide their interpretation.
Alexander Meadway, Lawrence C. Sincich
openaire   +2 more sources

Thyroid hormone receptor beta-2 (TRβ2) overexpression modulates photoreceptor phenotype diversity in a ligand-dependent manner

Frontiers in Cell and Developmental Biology
BackgroundVertebrate color vision results from the specification of photoreceptor subtypes expressing distinct opsins. Thyroid hormone (TH) and its receptor TRβ2 are essential regulators of long-wavelength-sensitive (LWS) cone development, but their ...
Emmanuel Owusu Poku, Matthew R. Fonte, Matthew R. Fonte, Tyler J. Jensen, Tyler J. Jensen, Sydney P. Inman, Robert D. Mackin, Deborah L. Stenkamp   +7 more
doaj   +1 more source

Characterization and Transplantation of CD73-Positive Photoreceptors Isolated from Human iPSC-Derived Retinal Organoids

Stem Cell Reports, 2018
Summary: Photoreceptor degenerative diseases are a major cause of blindness for which cell replacement is one of the most encouraging strategies. For stem cell-based therapy using human induced pluripotent stem cells (hiPSCs), it is crucial to obtain a ...
Giuliana Gagliardi, Karim Ben M'Barek, Antoine Chaffiol, Amélie Slembrouck-Brec, Jean-Baptiste Conart, Céline Nanteau, Oriane Rabesandratana, José-Alain Sahel, Jens Duebel, Gael Orieux, Sacha Reichman, Olivier Goureau   +11 more
doaj   +1 more source

Resveratrol Protects Photoreceptors in Mouse Models of Retinal Degeneration

Antioxidants
Photoreceptor/retinal degeneration is the major cause of blindness. Induced and inherited mouse models of retinal degeneration are valuable tools for investigating disease mechanisms and developing therapeutic interventions.
Shujuan Li, Hongwei Ma, Xi-Qin Ding
doaj   +1 more source

Role of guanylyl cyclase modulation in mouse cone phototransduction [PDF]

, 2011
A negative phototransduction feedback in rods and cones is critical for the timely termination of their light responses and for extending their function to a wide range of light intensities. The calcium feedback mechanisms that modulate phototransduction
Chen, Jeannie, Kefalov, Vladimir J, Sakurai, Keisuke   +2 more
core   +2 more sources

Neurexin-1-dependent circuit activity is required for the maintenance of photoreceptor subtype identity in Drosophila

Molecular Brain
In the human and Drosophila color vision system, each photoreceptor neuron (cone cell in humans and R7/R8 photoreceptor cell in Drosophila) makes a stochastic decision to express a single photopigment of the same family with the exclusion of the others ...
Gabrielle Lim-Kian-Siang, Arianna R. Izawa-Ishiguro, Yong Rao   +2 more
doaj   +1 more source

Drosophila photoreceptor tethering by a laminin-Eys scaffold

iScience
Summary: Visual acuity in Drosophila requires precise photoreceptor alignment along the optical axis, maintained by longitudinal tension between a rigid cornea and a contractile retinal base. Here, we identify the rhabdomere caps—an extracellular matrix (
Donald F. Ready, Henry C. Chang
doaj   +1 more source

The Murine Cone Photoreceptor [PDF]

Neuron, 2000
Applebury, M.L, Antoch, M.P, Baxter, L.C, Chun, L.L.Y, Falk, J.D, Farhangfar, F, Kage, K, Krzystolik, M.G, Lyass, L.A, Robbins, J.T   +9 more
openaire   +1 more source