Induction of rod versus cone photoreceptor-specific progenitors from retinal precursor cells
Stem Cell Research, 2018 During development, multipotent progenitors undergo temporally-restricted differentiation into post-mitotic retinal cells; however, the mechanisms of progenitor division that occurs during retinogenesis remain controversial.
Saeed Khalili +12 more
doaj +4 more sources
cGMP-grade human iPSC-derived retinal photoreceptor precursor cells rescue cone photoreceptor damage in non-human primates [PDF]
Stem Cell Research & Therapy, 2021 Background Retinal regenerative therapies hold great promise for the treatment of inherited retinal degenerations (IRDs). Studies in preclinical lower mammal models of IRDs have suggested visual improvement following retinal photoreceptor precursors ...
Swathi Lingam +16 more
doaj +3 more sources
The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2 [PDF]
Free Radical Biology and Medicine, 2019 Sylvia B Smith
exaly +4 more sources
Notch signaling represses cone photoreceptor formation through the regulation of retinal progenitor cell states [PDF]
Scientific Reports, 2021 Notch signaling is required to repress the formation of vertebrate cone photoreceptors and to maintain the proliferative potential of multipotent retinal progenitor cells.
Xueqing Chen, Mark M. Emerson
doaj +2 more sources
SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration [PDF]
Life Science Alliance, 2020 This study reports that activation of SARM1 causes destruction of NAD pools in photoreceptor cells of the retina and identifies a role for SARM1-dependent photoreceptor cell death in retinal degeneration.
Ema Ozaki +10 more
doaj +2 more sources
Development and degeneration of cone bipolar cells are independent of cone photoreceptors in a mouse model of retinitis pigmentosa. [PDF]
PLoS ONE, 2012 Retinal photoreceptors die during retinal synaptogenesis in a portion of retinal degeneration. Whether cone bipolar cells establish regular retinal mosaics and mature morphologies, and resist degeneration are not completely understood.
Miao Chen, Ke Wang, Bin Lin
doaj +5 more sources
Stem Cell Reports, 2017 Summary: Loss of cone photoreceptors, crucial for daylight vision, has the greatest impact on sight in retinal degeneration. Transplantation of stem cell-derived L/M-opsin cones, which form 90% of the human cone population, could provide a feasible ...
Emily Welby +16 more
doaj +3 more sources
FGF2 Deficiency Modulates Early Microglial Responses Without Affecting Photoreceptor Survival in a Retinitis Pigmentosa Mouse Model [PDF]
CellsFibroblast growth factor 2 (FGF2) is expressed in retinal Müller glia cells, and its expression increases in response to photoreceptor degeneration. To investigate the physiological relevance of FGF2, we analyzed retinal morphology and cellular responses
Felia C. Haffelder +4 more
doaj +2 more sources
Microglial phagocytosis of bipolar cells triggers inner retinal degeneration in Rs1-KO mice [PDF]
Cell Communication and SignalingBackground X-linked juvenile retinoschisis (XLRS) is a hereditary retinal disorder caused by mutations in the RS1 gene that leads to the formation of cavities in the inner nuclear layer (INL) and progressive vision loss, characterized by a ...
Jin Young Yang +10 more
doaj +2 more sources
Melanopsin Retinal Ganglion Cells Regulate Cone Photoreceptor Lamination in the Mouse Retina [PDF]
Cell Reports, 2018 Pierre Mattar +2 more
exaly +2 more sources