A Positive Feedback Synapse from Retinal Horizontal Cells to Cone Photoreceptors
PLoS Biology, 2011 Cone photoreceptors and horizontal cells (HCs) have a reciprocal synapse that underlies lateral inhibition and establishes the antagonistic center-surround organization of the visual system. Cones transmit to HCs through an excitatory synapse and HCs feed back to cones through an inhibitory synapse.
Skyler L. Jackman +4 more
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Quantitative and Topographical Analysis of the Losses of Cone Photoreceptors and Retinal Ganglion Cells Under Taurine Depletion [PDF]
Investigative Opthalmology & Visual Science, 2016 Taurine depletion is known to induce photoreceptor degeneration and was recently found to also trigger retinal ganglion cell (RGC) loss similar to the retinal toxicity of vigabatrin. Our objective was to study the topographical loss of RGCs and cone photoreceptors, with a distinction between the two cone types (S- and L- cones) in an animal model of ...
Wahiba Hadj‐Saïd +14 more
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Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea [PDF]
Cell Stem Cell, 2022 High-definition vision in humans and nonhuman primates is initiated by cone photoreceptors located within a specialized region of the retina called the fovea. Foveal cone death is the ultimate cause of central blindness in numerous retinal dystrophies, including macular degenerative diseases.
Aindrila Saha +5 more
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Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors [PDF]
Stem Cell Reports, 2017 Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited blindness. However, humans depend more upon cone photoreceptors that are required for daylight, color, and high-acuity vision.
Anai Gonzalez-Cordero +19 more
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A transgenic mice model of retinopathy of cblG-type inherited disorder of one-carbon metabolism highlights epigenome-wide alterations related to cone photoreceptor cells development and retinal metabolism [PDF]
Clinical Epigenetics, 2023 AbstractBackgroundMTRgene encodes the cytoplasmic enzyme methionine synthase, which plays a pivotal role in the methionine cycle of one-carbon metabolism. This cycle holds a significant importance in generating S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), the respective universal methyl donor and end-product of epigenetic ...
Karim Matmat +14 more
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A Dynamic Change of Microglial States Occurs During the Transition From Photoreceptor Degeneration to Regeneration in Zebrafish pde6c Mutants. [PDF]
GliaZebrafish pde6c mutants undergo photoreceptor degeneration from 5 dpf, but rods regenerate from 4 wpf. scRNA‐seq of retinal microglia reveals dynamic change of states between 5 dpf and 4 wpf. Two states emerge specifically during regeneration. ABSTRACT Microglia, brain‐resident immune cells, maintain brain homeostasis.
Ravishankar D, Takeuchi Y, Masai I.
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Differences in calcium homeostasis between retinal rod and cone photoreceptors revealed by the effects of voltage on the cGMP-gated conductance in intact cells. [PDF]
The Journal of general physiology, 1994 We measured currents under voltage clamp in intact retinal rod photoreceptors with tight seal electrodes in the perforated patch mode. In the dark, membrane depolarization to voltages > or = +20 mV activates a time- and voltage-dependent outward current in the outer segment.
James L. Miller, Juan I. Korenbrot
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Developing a simple method to enhance the generation of cone and rod photoreceptors in pluripotent stem cell-derived retinal organoids [PDF]
Stem Cells, 2019 Abstract Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse diseases such as Stargardt's disease, age-related macular degeneration, and retinitis pigmentosa. The final impact of all retinal dystrophies is the loss of photoreceptors; hence, there is a pressing need for research into ...
Darin Zerti +7 more
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, 2021 Cones are the color-detecting photoreceptors of the vertebrate eye. Cones are specialized into subtypes whose functions are determined by the expression of color-sensitive opsin proteins. Organisms differ greatly in the number and patterning of cone subtypes.
Christina McNerney, Robert J. Johnston
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