Induction of Neuronal Morphology in the 661W Cone Photoreceptor Cell Line with Staurosporine. [PDF]
PLoS ONE, 2015 PURPOSE:RGC-5 cells undergo differentiation into a neuronal phenotype with low concentrations of staurosporine. Although the RGC-5 cell line was initially thought to be of retinal ganglion cell origin, recent evidence suggests that the RGC-5 line could ...
Alex F Thompson +3 more
doaj +1 more source
Necrotic cone photoreceptor cell death in retinitis pigmentosa [PDF]
Cell Death & Disease, 2015 Retinitis pigmentosa (RP) comprises a group of inherited retinal degenerations, resulting from rod and cone photoreceptor cell death. Genetic studies have identified mutations in more than 50 genes—most of which encode rod-related molecules—that are associated with RP.
Murakami, Y +6 more
openaire +2 more sources
Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system
Molecular vision, 2010 peer ...
Lavinia Bhatt +3 more
openalex +5 more sources
Cell-specific DNA methylation patterns of retina-specific genes. [PDF]
PLoS ONE, 2012 Many studies have demonstrated that epigenetic mechanisms are important in the regulation of gene expression during embryogenesis, gametogenesis, and other forms of tissue-specific gene regulation.
Shannath L Merbs +6 more
doaj +1 more source
AAV9 targets cone photoreceptors in the nonhuman primate retina. [PDF]
PLoS ONE, 2013 Transduction of retinal pigment epithelial cells with an adeno-associated viral vector (AAV) based on serotype 2 has partially corrected retinal blindness in Leber congenital amaurosis type 2.
Luk H Vandenberghe +7 more
doaj +1 more source
Universality of Form: The Case of Retinal Cone Photoreceptor Mosaics
Entropy, 2023 Cone photoreceptor cells are wavelength-sensitive neurons in the retinas of vertebrate eyes and are responsible for color vision. The spatial distribution of these nerve cells is commonly referred to as the cone photoreceptor mosaic.
Alireza Beygi
doaj +1 more source
Subretinal gene therapy delays vision loss in a Bardet-Biedl Syndrome type 10 mouse model
Molecular Therapy: Nucleic Acids, 2023 Blindness in Bardet-Biedl syndrome (BBS) is caused by dysfunction and loss of photoreceptor cells in the retina. BBS10, mutations of which account for approximately 21% of all BBS cases, encodes a chaperonin protein indispensable for the assembly of the ...
Ying Hsu +12 more
doaj +1 more source
Investigation of adaptive optics imaging biomarkers for detecting pathological changes of the cone mosaic in patients with type 1 diabetes mellitus [PDF]
, 2016 Purpose To investigate a set of adaptive optics (AO) imaging biomarkers for the assessment of changes of the cone mosaic spatial arrangement in patients with type 1 diabetes mellitus (DM1).
Giannini, Daniela +5 more
core +6 more sources
Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light‐induced damage [PDF]
Journal of Neurochemistry, 2012 J. Neurochem. (2012) 121, 146–156.AbstractAll‐trans‐retinal and its condensation‐products can cause retinal degeneration in a light‐dependent manner and contribute to the pathogenesis of human macular diseases such as Stargardt’s disease and age‐related macular degeneration.
Kiichiro, Okano +9 more
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