Results 51 to 60 of about 33,197 (253)

Dysflective cones: Visual function and cone reflectivity in long-term follow-up of acute bilateral foveolitis. [PDF]

, 2017
PURPOSE:Confocal adaptive optics scanning laser ophthalmoscope (AOSLO) images provide a sensitive measure of cone structure. However, the relationship between structural findings of diminished cone reflectivity and visual function is unclear.
Cunningham, Emmett T, Duncan, Jacque L, Foote, Katharina G, Gorin, Michael B, Lujan, Brandon J, Qin, Jia, Ratnam, Kavitha, Roorda, Austin, Tu, Joanna H, Tuten, William S   +9 more
core   +1 more source

Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors

Cell Reports, 2021
Summary: Age-related macular degeneration and other macular diseases result in the loss of light-sensing cone photoreceptors, causing irreversible sight impairment.
Joana Ribeiro, Christopher A. Procyk, Emma L. West, Michelle O’Hara-Wright, Monica F. Martins, Majid Moshtagh Khorasani, Aura Hare, Mark Basche, Milan Fernando, Debbie Goh, Neeraj Jumbo, Matteo Rizzi, Kate Powell, Menahil Tariq, Michel Michaelides, James W.B. Bainbridge, Alexander J. Smith, Rachael A. Pearson, Anai Gonzalez-Cordero, Robin R. Ali   +19 more
doaj   +1 more source

Necrotic enlargement of cone photoreceptor cells and the release of high-mobility group box-1 in retinitis pigmentosa [PDF]

Cell Death Discovery, 2015
AbstractRetinitis pigmentosa (RP) refers to a group of inherited retinal degenerations resulting form rod and cone photoreceptor cell death. The rod cell death due to deleterious genetic mutations has been shown to occur mainly through apoptosis, whereas the mechanisms and features of the secondary cone cell death have not been fully elucidated.
Murakami, Y, Ikeda, Y, Nakatake, S, Tachibana, T, Fujiwara, K, Yoshida, N, Notomi, S, Nakao, S, Hisatomi, T, Miller, J W, Vavvas, DG, Sonoda, KH, Ishibashi, T   +12 more
openaire   +3 more sources

Evaluating Descriptive Metrics of the Human Cone Mosaic [PDF]

, 2016
Purpose: To evaluate how metrics used to describe the cone mosaic change in response to simulated photoreceptor undersampling (i.e., cell loss or misidentification).
Carroll, Joseph, Cooper, Robert F., Tarima, Sergey, Wilk, Melissa A.   +3 more
core   +2 more sources

Rapamycin Improved Retinal Function and Morphology in a Mouse Model of Retinal Degeneration

Frontiers in Neuroscience, 2022
The retina is an important visual organ, which is responsible for receiving light signals and transmitting them to the optic nerve center step by step.
Meng Zhao, Meng Zhao, Houting Lv, Houting Lv, Na Yang, Na Yang, Guang-Hua Peng, Guang-Hua Peng   +7 more
doaj   +1 more source

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. [PDF]

, 2017
The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of reliable methods to culture complex retinal tissues from human pluripotent stem cells (hPSCs) could ...
Angueyra, Juan M, Ball, John, Grebe, Rhonda, Jones, Bryan W, Kim, Catherine, Li, Wei, Maruotti, Julien A, Sripathi, Srinivasa R, Wahlin, Karl J, Zack, Donald J   +9 more
core   +1 more source

Cis-regulatory basis of sister cell type divergence in the vertebrate retina [PDF]

, 2019
Multicellular organisms evolved via repeated functional divergence of transcriptionally related sister cell types, but the mechanisms underlying sister cell type divergence are not well understood.
Corbo, Joseph C, Hughes, Andrew E.O., Lawrence, Karen A, Murphy, Daniel P, Myers, Connie A   +4 more
core   +3 more sources

661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively

Scientific Reports, 2017
A photoreceptor cell line, 661W, derived from a mouse retinal tumor that expresses several markers of cone photoreceptor cells has been described earlier. However, these cells can be differentiated into neuronal cells. Here, we report that this cell line
Zuberwasim Sayyad, Kapil Sirohi, Vegesna Radha, Ghanshyam Swarup   +3 more
doaj   +1 more source

Molecular characterization of MAP9 in the photoreceptor sensory cilia as a modifier in canine RPGRIP1-associated cone-rod dystrophy

Frontiers in Cellular Neuroscience, 2023
Photoreceptors possess a highly specialized primary cilium containing expanded ciliary membrane discs called the outer segment. The photoreceptor cilium is essential for the maintenance of the outer segment, and pathogenic variants in more than 50 cilia ...
Kei Takahashi, Jennifer C. Kwok, Yu Sato, Gustavo D. Aguirre, Keiko Miyadera   +4 more
doaj   +1 more source

Photo-damage, photo-protection and age-related macular degeneration [PDF]

, 2015
Age-related macular degeneration (AMD) is a degenerative retinal disease that causes blindness in people 60-65 years and older, with the highest prevalence appearing in people 90 years-old or more.
Marquioni Ramella, Melisa Daniela, Suburo, Angela Maria   +1 more
core   +1 more source