Regeneration of cone photoreceptors when cell ablation is primarily restricted to a particular cone subtype. [PDF]
PLoS ONE, 2013 We sought to characterize the regenerated cells, if any, when photoreceptor ablation was mostly limited to a particular cone subtype. This allowed us to uniquely assess whether the remaining cells influence specification of regenerating photoreceptors ...
Brittany Fraser +3 more
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Frontiers in Genetics, 2022 Retinitis pigmentosa and related photoreceptor dystrophies (RPRPD) are rare retinal diseases caused by hereditary gene mutations resulting in photoreceptor death, followed by vision loss.
Galina Dvoriantchikova +3 more
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Docosahexaenoic acid promotes photoreceptor differentiation without altering Crx expression [PDF]
, 2006 PURPOSE: The precise molecular cues required for photoreceptor development are still unknown. Pax6 and Crx are essential during early retinal development and for photoreceptor differentiation, respectively.
Garelli, Andres +2 more
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A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. [PDF]
PLoS Genetics, 2005 Rod and cone photoreceptors subserve vision under dim and bright light conditions, respectively. The differences in their function are thought to stem from their different gene expression patterns, morphologies, and synaptic connectivities. In this study,
Joseph C Corbo, Constance L Cepko
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Role of microglial cells in photoreceptor degeneration
Neural Regeneration Research, 2019 Inherited photoreceptor degeneration in humans constitutes a major cause of irreversible blindness in the world. They comprise various diseases, but retinitis pigmentosa is the most frequently observed. Retinitis pigmentosa is commonly limited to the eye,
Johnny Di Pierdomenico +4 more
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Sphingolipids as emerging mediators in retina degeneration [PDF]
, 2019 The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
Prado Spalm, Facundo Heber +3 more
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iScienceSummary: Primary and secondary cone photoreceptor death in retinal degenerative diseases, including age-related macular degeneration (AMD) and retinitis pigmentosa (RP), leads to severe visual impairment and blindness.
Leah Rie Varner +7 more
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Melanopsin and Cone Photoreceptor Inputs to the Afferent Pupil Light Response
Frontiers in Neurology, 2019 Background: Retinal photoreceptors provide the main stage in the mammalian eye for regulating the retinal illumination through changes in pupil diameter, with a small population of melanopsin-expressing intrinsically photosensitive retinal ganglion cells
Andrew J. Zele +7 more
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Potential role of Müller cells in the pathogenesis of macropsia associated with epiretinal membrane: a hypothesis revisited [PDF]
International Journal of Ophthalmology, 2017 Pathophysiological explanations for metamorphopsia associated with retinal pathologies generally focus on photoreceptor organization disruption. However, the retinal microarchitecture is complicated, and we hypothesize that other retinal cells may also ...
Ahmet Colakoglu, Solmaz Balci Akar
doaj +1 more source
Dysfunctional Light-Evoked Regulation of cAMP in Photoreceptors and Abnormal Retinal Adaptation in Mice Lacking Dopamine D4 Receptors [PDF]
, 2002 Dopamine is a retinal neuromodulator that has been implicated in many aspects of retinal physiology. Photoreceptor cells express dopamine D4 receptors that regulate cAMP metabolism.
Grandy, David K. +6 more
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