Results 81 to 90 of about 33,197 (253)

Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse.

PLoS ONE, 2014
Retinal neurodegeneration is a key component of diabetic retinopathy (DR), although the detailed neuronal damage remains ill-defined. Recent evidence suggests that in addition to amacrine and ganglion cell, diabetes may also impact on other retinal ...
Jose R Hombrebueno, Mei Chen, Rosana G Penalva, Heping Xu   +3 more
doaj   +1 more source

Photoreceptor Inner Segment Morphology in Best Vitelliform Macular Dystrophy [PDF]

, 2016
PURPOSE To characterize outer retina structure in best vitelliform macular dystrophy (BVMD) and to determine the effect of macular lesions on overlying and adjacent photoreceptors.
Carroll, Joseph, Cooper, Robert F., Dubra, Alfredo, Higgins, Brian P., Johnson, Ryan D., Scoles, Drew, Stepien, Kimberly E., Sulai, Yusufu N.   +7 more
core   +2 more sources

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

NAALAD2 mutations disrupt the fate of photoreceptor cells and retinal pigment epithelial cells during early retinal development

Pharmacological Research
In recent years, the global incidence of myopia has steadily increased, highlighting the importance of prevention and early intervention, particularly in the absence of effective treatments.
Yuanjie Qian, Jian Gao, Zheming Zhang, Yixuan Chen, Jindi Su, Xing Niu, Kaifeng Zheng, Yantao Bao, Yueyuan Qin, Junge Zheng, Yuankai Yang, Qunyan Wu, Ke Mo, Yantao Wei, Shan Duan   +14 more
doaj   +1 more source

Inner retinal change in a novel rd1-FTL mouse model of retinal degeneration

Frontiers in Cellular Neuroscience, 2015
While photoreceptor loss is the most devastating result of inherited retinal degenerations such as retinitis pigmentosa, inner retinal neurons also undergo significant alteration.
Ursula eGreferath, Emily E Anderson, Andrew I Jobling, Kirstan A Vessey, Gemma eMartinez, Robb U De Iongh, Michael eKalloniatis, Michael eKalloniatis, Erica Lucy Fletcher   +8 more
doaj   +1 more source

The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision [PDF]

, 2017
Calcium (Ca2+) plays an important role in the function and health of neurons. In vertebrate cone photoreceptors, Ca2+ controls photoresponse sensitivity, kinetics, and light adaptation.
Arden, Bauer, Baylor, Berridge, Bronckers, Bronckers, Calvert, Corbo, Dizhoor, Fain, Gorczyca, Herzog, Hu, Hughes, Ingram, Jalloul, Kang, Korenbrot, Lamason, Lamb, Le, Li, Li, Makino, Mattapallil, Matthews, Matveev, Mendez, Miller, Nakatani, Neuillé, Nikonov, Nikonov, Palczewski, Parry, Picones, Poetsch, Prieto, Prinsen, Pugh, Rebrik, Reiländer, Riazuddin, Sakurai, Sakurai, Sakurai, Sampath, Sampath, Schnetkamp, Schwarzer, Schwarzer, Seymen, Shichida, Shirato, Smith, Stephan, Sulem, Szél, Tachibanaki, Takemoto, Tomizuka, Tsoi, Vinberg, Vinberg, Vinberg, Wang, Wang, Winkler, Yau, Yau   +69 more
core   +2 more sources

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Disruption of the basal body protein POC1B results in autosomal-recessive cone-rod dystrophy [PDF]

, 2014
Exome sequencing revealed a homozygous missense mutation (c.317C>G [p.Arg106Pro]) in POC1B, encoding POC1 centriolar protein B, in three siblings with autosomal-recessive cone dystrophy or cone-rod dystrophy and compound-heterozygous POC1B mutations (c ...
Arts, Heleen H, Coppieters, Frauke, Cremers, Frans PM, De Baere, Elfride, de Vrieze, Erik, den Hollander, Anneke I, Hetterschijt, Lisette, Hoyng, Carel B, Kremer, Hannie, Lambertus, Stanley, Lamers, Ideke JC, Letteboer, Stef JF, Peters, Theo A, POC1B Study Group, the, Roepman, Ronald, Roosing, Susanne, van den Born, L Ingeborgh, van Wijk, Erwin   +17 more
core   +2 more sources

Human iPSC differentiation to retinal organoids in response to IGF1 and BMP4 activation is line- and method-dependent [PDF]

, 2020
Induced pluripotent stem cell (iPSC)‐derived retinal organoids provide a platform to study human retinogenesis, disease modeling, and compound screening.
Armstrong, Lyle, Carter, Madeleine, Chichagova, Valeria, Georgiou, Maria, Ghareeb, Ali, Hilgen, Gerrit, Lako, Majlinda, Sernagor, Evelyne   +7 more
core   +2 more sources

Correction: A transgenic mice model of retinopathy of cblG‑type inherited disorder of one‑carbon metabolism highlights epigenome‑wide alterations related to cone photoreceptor cells development and retinal metabolism [PDF]

Clinical Epigenetics
Karim Matmat, Jean‐Baptiste Conart, Paul‐Henri Graindorge, Sandra El Kouche, Ziad Hassan, Youssef Siblini, Rémy Umoret, Ramia Safar, Okan Baspinar, Aurélie Robert, Jean‐Marc Alberto, Abderrahim Oussalah, Sébastien Hergalant, David Coelho, Jean‐Louis Guéant, Rosa‐Maria Guéant‐Rodriguez   +15 more
openalex   +3 more sources