Results 111 to 120 of about 42,890 (207)

Retinitis pigmentosa: cone photoreceptors starving to death

Nature Neuroscience, 2009
In retinitis pigmentosa, rod and cone photoreceptors die. Although rods die as a consequence of rod-specific genetic mutations, there is no clear explanation for the progressive loss of cones. A new study in this issue suggests that changes in the insulin/mTOR pathway and cell starvation can partially account for cone death in this disease.
Bovolenta, Paola, Cisneros Niño, Elsa
openaire   +2 more sources

A novel mechanism of cone photoreceptor adaptation

PLOS Biology, 2017
An animal's ability to survive depends on its sensory systems being able to adapt to a wide range of environmental conditions, by maximizing the information extracted and reducing the noise transmitted. The visual system does this by adapting to luminance and contrast.
Marcus H. C. Howlett, Robert G. Smith, Maarten Kamermans   +2 more
openaire   +4 more sources

Structural but Not Functional Alterations in Cones in the Absence of the Retinal Disease Protein Retinitis Pigmentosa 2 (RP2) in a Cone-Only Retina

Frontiers in Genetics, 2019
X-linked retinitis pigmentosa 2 (XLRP2) patients and Rp2null mice exhibit severe cone photoreceptor degeneration. However, due to the paucity of cones in mammalian model systems, it is not clear how cones respond to the loss of RP2. Here we have used the
Linjing Li, Kollu N. Rao, Hemant Khanna
doaj   +1 more source

Assessment of photoreceptor recovery and visual function utilizing adaptive optics and microperimetry in patients with surgically closed macular holes

Photodiagnosis and Photodynamic Therapy
Background: This study investigated the association between photoreceptor structural restoration and visual function outcomes in patients undergoing surgery for closed macular holes (MHs).
Yuanyuan Liu, Xueli Yang, Wei Zhou, Jinguo Yu, Song Chen, Tiangeng He, Caiyun You, Xiangda Meng, Mengyu Liao, Yi Lei, Hua Yan   +10 more
doaj   +1 more source

Loss of Foveal Cone Structure Precedes Loss of Visual Acuity in Patients With Rod-Cone Degeneration. [PDF]

, 2019
PurposeTo assess the relationship between cone spacing and visual acuity in eyes with rod-cone degeneration (RCD) followed longitudinally.MethodsHigh-resolution images of the retina were obtained using adaptive optics scanning laser ophthalmoscopy from ...
Bensinger, Ethan, Duncan, Jacque L, Griffin, Shane, Loumou, Panagiota, Porco, Travis C, Qin, Jia, Ratnam, Kavitha, Rinella, Nicholas, Roorda, Austin, Saud, Asma   +9 more
core  

A Neural Network Model for the Spatial and Temporal Response of Retinal Ganglion Cells [PDF]

, 1991
This article introduces a quantitative model of early visual system function. The model is formulated to unify analyses of spatial and temporal information processing by the nervous system. Functional constraints of the model suggest mechanisms analogous
Gaudiano, Paolo
core   +1 more source

Pathomechanisms of ATF6-Associated Cone Photoreceptor Diseases

, 2019
Activating transcription factor 6 (ATF6) is a key regulator of the unfolded protein response (UPR). In response to endoplasmic reticulum (ER) stress, ATF6 is transported from the ER to the Golgi apparatus where it is cleaved by intramembrane proteolysis, releasing its cytosolic fragment. The cleaved ATF6 fragment, which is a basic leucine zipper (bZip)
Wei-Chieh Jerry, Chiang, Heike, Kroeger, Lulu, Chea, Jonathan H, Lin   +3 more
openaire   +3 more sources

Episodic live imaging of cone photoreceptor maturation in GNAT2-EGFP retinal organoids. [PDF]

Dis Model Mech, 2023
Bai J, Koos DS, Stepanian K, Fouladian Z, Shayler DWH, Aparicio JG, Fraser SE, Moats RA, Cobrinik D.   +8 more
europepmc   +1 more source

Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function [PDF]

, 2018
Visual function in vertebrates critically depends on the continuous regeneration of visual pigments in rod and cone photoreceptors. RPE65 is a well-established retinoid isomerase in the pigment epithelium that regenerates rhodopsin during the rod visual ...
Angueyra, Juan M, Badiee, Mohsen, Kefalov, Vladimir J, Kinoshita, Junzo, Kiser, Philip D, Kolesnikov, Alexander V, Li, Wei, Palczewski, Krzysztof, Peachey, Neal S, Sharma, Aditya, Tochtrop, Gregory P, Zhang, Jianye   +11 more
core   +1 more source

NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development

The Journal of Clinical Investigation
While dysfunction and death of light-detecting photoreceptor cells underlie most inherited retinal dystrophies, knowledge of the species-specific details of human rod and cone photoreceptor cell development remains limited.
Nathaniel K. Mullin, Laura R. Bohrer, Andrew P. Voigt, Lola P. Lozano, Allison T. Wright, Vera L. Bonilha, Robert F. Mullins, Edwin M. Stone, Budd A. Tucker   +8 more
doaj   +1 more source