Results 11 to 20 of about 42,890 (207)

Daily mitochondrial dynamics in cone photoreceptors [PDF]

Proceedings of the National Academy of Sciences, 2020
Significance Mitochondria are organelles that make cellular energy. In the retina, mitochondrial health is important for photoreceptor cell function and normal vision. Photoreceptors need more energy at night, but it is unclear how their mitochondria adapt to changing energy demands.
Michelle M. Giarmarco, Daniel C. Brock, Brian M. Robbings, Whitney M. Cleghorn, Kristine A. Tsantilas, Kellie C. Kuch, William Ge, Kaitlyn M. Rutter, Edward D. Parker, James B. Hurley, Susan E. Brockerhoff   +10 more
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Structure of cone photoreceptors [PDF]

Progress in Retinal and Eye Research, 2009
Although outnumbered more than 20:1 by rod photoreceptors, cone cells in the human retina mediate daylight vision and are critical for visual acuity and color discrimination. A variety of human diseases are characterized by a progressive loss of cone photoreceptors but the low abundance of cones and the absence of a macula in non-primate mammalian ...
Mustafi, D., Engel, A. H., Palczewski, K.   +2 more
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Membrane conductances of mouse cone photoreceptors [PDF]

Journal of General Physiology, 2020
Vertebrate photoreceptor cells respond to light through a closure of CNG channels located in the outer segment. Multiple voltage-sensitive channels in the photoreceptor inner segment serve to transform and transmit the light-induced outer-segment current response. Despite extensive studies in lower vertebrates, we do not know how these channels produce
Norianne T. Ingram, Alapakkam P. Sampath, Gordon L. Fain   +2 more
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Elevated energy requirement of cone photoreceptors [PDF]

Proceedings of the National Academy of Sciences, 2020
SignificanceFrom recent measurements of mammalian cone physiology, we have calculated cone ATP utilization in darkness and in the light. We show that single cones consume ATP at a much higher rate than single rods, a difference that is greatly increased during the day.
Norianne T. Ingram, Gordon L. Fain, Alapakkam P. Sampath   +2 more
openaire   +4 more sources

Disease-causing mutations in genes encoding transcription factors critical for photoreceptor development

Frontiers in Molecular Neuroscience, 2023
Photoreceptor development of the vertebrate visual system is controlled by a complex transcription regulatory network. OTX2 is expressed in the mitotic retinal progenitor cells (RPCs) and controls photoreceptor genesis.
Chi Sun, Shiming Chen, Shiming Chen
doaj   +1 more source

Childhood-onset genetic cone-rod photoreceptor diseases and underlying pathobiology

EBioMedicine, 2021
Inherited retinal diseases (IRDs) were first classified clinically by history, ophthalmoscopic appearance, type of visual field defects, and electroretinography (ERG).
Alexandra V. Garafalo, Rebecca Sheplock, Alexander Sumaroka, Alejandro J. Roman, Artur V. Cideciyan, Samuel G. Jacobson   +5 more
doaj   +1 more source

Cone photoreceptors in laminated retinal transplants [PDF]

Acta Ophthalmologica Scandinavica, 2001
ABSTRACT. Purpose: To investigate the contents of green‐ and blue‐sensitive cone photoreceptors in laminated rabbit retinal transplants.Methods: Eleven rabbits each received a sheet of embryonic neuroretina into the subretinal space in one eye. Vitrectomy was used in the procedure and properly polarized flat transplants were placed on the host pigment ...
K, Gjörloff, A, Bruun, F, Ghosh
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Automated Cone Photoreceptor Cell Segmentation and Identification in Adaptive Optics Scanning Laser Ophthalmoscope Images Using Morphological Processing and Watershed Algorithm

IEEE Access, 2020
Geometrical analysis of cone photoreceptor cells is important not only for ophthalmic diagnosis, but also for research on eye diseases. In this study, an automated cone photoreceptor cell segmentation and identification method based on morphological ...
Yiwei Chen, Yi He, Jing Wang, Wanyue Li, Lina Xing, Feng Gao, Guohua Shi   +6 more
doaj   +1 more source

Surround Antagonism in Macaque Cone Photoreceptors [PDF]

The Journal of Neuroscience, 2003
Center-surround antagonism is a hallmark feature of the receptive fields of sensory neurons. In retinas of lower vertebrates, surround antagonism derives in part from inhibition of cone photoreceptors by horizontal cells. Using whole-cell patch recording methods, we found that light-evoked responses of cones in macaque monkey were antagonized when ...
Jan, Verweij, Eric P, Hornstein, Julie L, Schnapf   +2 more
openaire   +2 more sources

The Relationship Between Perifoveal L-Cone Isolating Visual Acuity and Cone Photoreceptor Spacing—Understanding the Transition Between Healthy Aging and Early AMD

Frontiers in Aging Neuroscience, 2021
Background: Age-related macular degeneration (AMD) is a multifactorial degenerative disorder that can lead to irreversible loss of visual function, with aging being the prime risk factor.
Rigmor C. Baraas, Åshild Horjen, Stuart J. Gilson, Hilde R. Pedersen   +3 more
doaj   +1 more source