Results 21 to 30 of about 42,890 (207)
AAV9 targets cone photoreceptors in the nonhuman primate retina. [PDF]
PLoS ONE, 2013 Transduction of retinal pigment epithelial cells with an adeno-associated viral vector (AAV) based on serotype 2 has partially corrected retinal blindness in Leber congenital amaurosis type 2.
Luk H Vandenberghe +7 more
doaj +1 more source
Zebrafish Models of Photoreceptor Dysfunction and Degeneration
Biomolecules, 2021 Zebrafish are an instrumental system for the generation of photoreceptor degeneration models, which can be utilized to determine underlying causes of photoreceptor dysfunction and death, and for the analysis of potential therapeutic compounds, as well as
Nicole C. L. Noel +2 more
doaj +1 more source
Cell Reports, 2018 Summary: In the vertebrate retina, cone photoreceptors play crucial roles in photopic vision by transmitting light-evoked signals to ON- and/or OFF-bipolar cells.
Akiko Ueno +12 more
doaj +1 more source
Assessing Photoreceptor Structure Associated with Ellipsoid Zone Disruptions Visualized with Optical Coherence Tomography [PDF]
, 2016 Purpose: To compare images of photoreceptor layer disruptions obtained with optical coherence tomography (OCT) and adaptive optics scanning light ophthalmoscopy (AOSLO) in a variety of pathologic states.Methods: Five subjects with photoreceptor ellipsoid
Carroll, Joseph +10 more
core +2 more sources
Glutamate Spillover between Mammalian Cone Photoreceptors [PDF]
The Journal of Neuroscience, 2011 Cone photoreceptors transmit signals at high temporal frequencies and mediate fine spatial vision. High-frequency transmission requires a high rate of glutamate release, which could promote spillover to neighboring cells, whereas spatial vision requires that cones within a tightly packed array signal light to postsynaptic bipolar cells with minimal ...
Brett A, Szmajda, Steven H, Devries
openaire +2 more sources
Cell-specific DNA methylation patterns of retina-specific genes. [PDF]
PLoS ONE, 2012 Many studies have demonstrated that epigenetic mechanisms are important in the regulation of gene expression during embryogenesis, gametogenesis, and other forms of tissue-specific gene regulation.
Shannath L Merbs +6 more
doaj +1 more source
Cell Reports, 2017 Circadian clocks regulate various aspects of photoreceptor physiology, but their contribution to photoreceptor development and function is unclear. Cone photoreceptors are critical for color vision.
Onkar B. Sawant +6 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Bardet-Biedl syndrome (BBS) is a heterogeneous and pleiotropic autosomal recessive disorder characterized by obesity, retinal degeneration, polydactyly, renal dysfunction, and mental retardation.
Ping Song +6 more
doaj +1 more source
The Effect of Cone Opsin Mutations on Retinal Structure and the Integrity of the Photoreceptor Mosaic [PDF]
, 2012 Purpose. To evaluate retinal structure and photoreceptor mosaic integrity in subjects with OPN1LW and OPN1MW mutations. Methods. Eleven subjects were recruited, eight of whom have been previously described.
Banin, Eyal +19 more
core +2 more sources
Noninvasive imaging of the thirteen-lined ground squirrel photoreceptor mosaic. [PDF]
, 2016 Ground squirrels are an increasingly important model for studying visual processing, retinal circuitry, and cone photoreceptor function. Here, we demonstrate that the photoreceptor mosaic can be longitudinally imaged noninvasively in the 13-lined ground ...
Dubra, Alfredo +6 more
core +1 more source