Results 51 to 60 of about 42,890 (207)
Light Adaptation in Salamander L-Cone Photoreceptors [PDF]
The Journal of Neuroscience, 2008 The responses of individual salamander L-cones to light steps of moderate intensity (bleaching 0.3–3% of the total photopigment) and duration (between 5 and 90 s) were recorded using suction electrodes. Light initially suppressed the circulating current, which partially recovered or “sagged” over several seconds.
Frederick S, Soo +2 more
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Cancer metabolism of cone photoreceptors
Oncotarget, 2015 Cancer cells divert cellular physiology for their own growth through activation of proto-oncogenes and inactivation of tumor suppressors by somatic mutations, amplifications, translocations and loss of alleles. The multistep tumor progression is a succession of clonal expansions of cells with mutant genotypes that acquire traits that enable them to ...
openaire +2 more sources
Calcium dynamics change in degenerating cone photoreceptors [PDF]
Human Molecular Genetics, 2016 Cone photoreceptors (cones) are essential for high-resolution daylight vision and colour perception. Loss of cones in hereditary retinal diseases has a dramatic impact on human vision. The mechanisms underlying cone death are poorly understood, and consequently, there are no treatments available. Previous studies suggest a central role for calcium (Ca2+
Manoj Kulkarni +4 more
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Rpgrip1 is required for rod outer segment development and ciliary protein trafficking in zebrafish [PDF]
, 2017 The authors would like to thank the Royal Society of London, the National Eye Research Centre, the Visual Research Trust, Fight for Sight, the W.H. Ross Foundation, the Rosetrees Trust, and the Glasgow Children’s Hospital Charity for supporting this work.
A Eblimit +54 more
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Cone fusion confusion in photoreceptor transplantation [PDF]
Stem Cell Investigation, 2017 Advances in stem cell biology have highlighted the potential for the eye as an ideal model in which to understand the mechanisms of neuronal repair. It is therefore not entirely surprising that the first reported allograft from one human to another also occurred in the eye, but over 100 years ago, with the successful corneal transplant performed by ...
openaire +2 more sources
PLoS ONE, 2014 PurposeIt has not been clarified whether early age-related macular degeneration (AMD) is associated with cone photoreceptor distribution. We used adaptive optics fundus camera to examine cone photoreceptors in the macular area of aged patients and ...
Ryo Obata, Yasuo Yanagi
doaj +1 more source
Robust cone-mediated signaling persists late into rod photoreceptor degeneration
eLife, 2022 Rod photoreceptor degeneration causes deterioration in the morphology and physiology of cone photoreceptors along with changes in retinal circuits. These changes could diminish visual signaling at cone-mediated light levels, thereby limiting the efficacy
Miranda L Scalabrino +7 more
doaj +1 more source
Dysfunctional Light-Evoked Regulation of cAMP in Photoreceptors and Abnormal Retinal Adaptation in Mice Lacking Dopamine D4 Receptors [PDF]
, 2002 Dopamine is a retinal neuromodulator that has been implicated in many aspects of retinal physiology. Photoreceptor cells express dopamine D4 receptors that regulate cAMP metabolism.
Grandy, David K. +6 more
core +1 more source
Wild-Type Cone Photoreceptors Persist Despite Neighboring Mutant Cone Degeneration [PDF]
The Journal of Neuroscience, 2010 In many retinal diseases, the malfunction that results in photoreceptor loss occurs only in either rods or cones, but degeneration can progress from the affected cell type to its healthy neighbors. Specifically, in human and mouse models of Retinitis Pigmentosa the loss of rods results in the death of neighboring healthy cones ...
Alaron, Lewis +4 more
openaire +2 more sources
The science of color and color vision [PDF]
, 2021 A survey of color science and color ...
Byrne, Alex, Hilbert, David R.
core