Results 61 to 70 of about 42,890 (207)

Phagocytosis of Retinal Rod and Cone Photoreceptors [PDF]

Physiology, 2010
Photoreceptor cells maintain a roughly constant length by continuously generating new outer segments from their base while simultaneously releasing mature outer segments engulfed by the retinal pigment epithelium (RPE). Thus postmitotic RPE cells phagocytose an immense amount of material over a lifetime, disposing of photoreceptor cell waste while ...
Brian M, Kevany, Krzysztof, Palczewski
openaire   +2 more sources

Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo [PDF]

, 2016
Whether neurons can restore their original connectivity patterns during circuit repair is unclear. Taking advantage of the regenerative capacity of zebrafish retina, we show here the remarkable specificity by which surviving neurons reassemble their ...
A Carleton, A Nissant, A Suli, AB Neef, AC Barber, BE Reese, BW Jones, CR Shields, DA Laplagne, E Strettoi, F Rossi, FD D’Orazi, G Salbreux, H Pisharath, HT Cline, J Schindelin, JM Davison, JR Lenkowski, JR Sanes, JZ Parrish, K Eliasieh, KA Michelsen, KM Christian, KM Kwan, M Takechi, M Takechi, MA Raven, MA Samuel, MJ Phillips, MS Singh, N Cuenca, N Toni, PR Johns, R Christensen, R Vroman, RA Poché, RE MacLaren, S Michalakis, S Yogev, SC Suzuki, SSP Magavi, T Puthussery, T Yoshimatsu, TS Vihtelic, W Haq, WB Thoreson, X Liu, Y Ueki, YN Li, YW Peng   +49 more
core   +1 more source

Melanopsin and Cone Photoreceptor Inputs to the Afferent Pupil Light Response

Frontiers in Neurology, 2019
Background: Retinal photoreceptors provide the main stage in the mammalian eye for regulating the retinal illumination through changes in pupil diameter, with a small population of melanopsin-expressing intrinsically photosensitive retinal ganglion cells
Andrew J. Zele, Andrew J. Zele, Prakash Adhikari, Prakash Adhikari, Dingcai Cao, Beatrix Feigl, Beatrix Feigl, Beatrix Feigl   +7 more
doaj   +1 more source

Sphingolipids as emerging mediators in retina degeneration [PDF]

, 2019
The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
Prado Spalm, Facundo Heber, Rotstein, Nora Patricia, Simon, Maria Victoria, Vera, Marcela Sonia   +3 more
core   +1 more source

Intensity-based optoretinography reveals sub-clinical deficits in cone function in retinitis pigmentosa

Frontiers in Ophthalmology
IntroductionClinical tools have been widely used in the diagnosis, description, and monitoring the progression of retinitis pigmentosa (RP); however, many of these methods have inherently low sensitivity and specificity, and significant photoreceptor ...
Mina Gaffney, Thomas B. Connor, Robert F. Cooper, Robert F. Cooper   +3 more
doaj   +1 more source

Macular cone abnormalities in retinitis pigmentosa with preserved central vision using adaptive optics scanning laser ophthalmoscopy. [PDF]

PLoS ONE, 2013
PURPOSE: To assess macular photoreceptor abnormalities in eyes with retinitis pigmentosa (RP) with preserved central vision using adaptive optics scanning laser ophthalmoscopy (AO-SLO). METHODS: Fourteen eyes of 14 patients with RP (best-corrected visual
Yukiko Makiyama, Sotaro Ooto, Masanori Hangai, Kohei Takayama, Akihito Uji, Akio Oishi, Ken Ogino, Satoko Nakagawa, Nagahisa Yoshimura   +8 more
doaj   +1 more source

\u3cem\u3eIn vivo\u3c/em\u3e Imaging of Human Cone Photoreceptor Inner Segments [PDF]

, 2014
Purpose. An often overlooked prerequisite to cone photoreceptor gene therapy development is residual photoreceptor structure that can be rescued. While advances in adaptive optics (AO) retinal imaging have recently enabled direct visualization of ...
Carroll, Joseph, Curcio, Christine A., Dubra, Alfredo, Fishman, Gerald A., Langlo, Christopher S., Scoles, Drew, Sulai, Yusufu N.   +6 more
core   +1 more source

Dysflective cones: Visual function and cone reflectivity in long-term follow-up of acute bilateral foveolitis. [PDF]

, 2017
PURPOSE:Confocal adaptive optics scanning laser ophthalmoscope (AOSLO) images provide a sensitive measure of cone structure. However, the relationship between structural findings of diminished cone reflectivity and visual function is unclear.
Cunningham, Emmett T, Duncan, Jacque L, Foote, Katharina G, Gorin, Michael B, Lujan, Brandon J, Qin, Jia, Ratnam, Kavitha, Roorda, Austin, Tu, Joanna H, Tuten, William S   +9 more
core   +1 more source

Ontogeny of cone photoreceptor mosaics in zebrafish [PDF]

Journal of Comparative Neurology, 2010
AbstractCone photoreceptors in fish are typically arranged into a precise, reiterated pattern known as a “cone mosaic.” Cone mosaic patterns can vary in different fish species and in response to changes in habitat, yet their function and the mechanisms of their development remain speculative.
Allison, W. Ted, Barthel, Linda K., Skebo, Kristina M., Takechi, Masaki, Kawamura, Shoji, Raymond, Pamela A.   +5 more
openaire   +3 more sources

In vivo efficacy of NRL knockdown with cell-penetrating siRNA in retinal degeneration

Scientific Reports
Retinal degenerative diseases, such as retinitis pigmentosa (RP) and age‑related macular degeneration (AMD), lead to progressive vision loss through photoreceptor degeneration; RP begins with the gradual loss of peripheral rods, whereas AMD causes ...
Hyungwoo Lee, Hyoik Jang, Jae-Byoung Chae, Hyo Kyung Lee, Chanok Son, Chul-Woo Park, Taejeong Ha, Munjeong Yum, Sungmi Park, Sun Woo Hong, Suk Young Lee, Jungmook Lyu, Semin Lee, Dong Ki Lee, Hyewon Chung   +14 more
doaj   +1 more source