Results 71 to 80 of about 42,890 (207)

Rod and Cone Photoreceptor Function in Patients with Cone Dystrophy

Investigative Opthalmology & Visual Science, 2004
To determine the extent of rod and cone photoreceptor dysfunction in patients with cone dystrophy using psychophysical and electrophysiological tests.Ten patients with cone dystrophy participated. Rod and cone system psychophysical thresholds were measured as a function of retinal eccentricity.
Karen, Holopigian, Vivienne C, Greenstein, William, Seiple, Donald C, Hood, Ronald E, Carr   +4 more
openaire   +2 more sources

LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone Photoreceptors

Cell Reports, 2018
Summary: Cone photoreceptors scale dynamically the sensitivity of responses to maintain responsiveness across wide range of changes in luminance. Synaptic changes contribute to this adaptation, but how this process is coordinated at the molecular level ...
Ignacio Sarria, Yan Cao, Yuchen Wang, Norianne T. Ingram, Cesare Orlandi, Naomi Kamasawa, Alexander V. Kolesnikov, Johan Pahlberg, Vladimir J. Kefalov, Alapakkam P. Sampath, Kirill A. Martemyanov   +10 more
doaj   +1 more source

Subretinal gene therapy delays vision loss in a Bardet-Biedl Syndrome type 10 mouse model

Molecular Therapy: Nucleic Acids, 2023
Blindness in Bardet-Biedl syndrome (BBS) is caused by dysfunction and loss of photoreceptor cells in the retina. BBS10, mutations of which account for approximately 21% of all BBS cases, encodes a chaperonin protein indispensable for the assembly of the ...
Ying Hsu, Sajag Bhattarai, Jacob M. Thompson, Angela Mahoney, Jacintha Thomas, Sara K. Mayer, Poppy Datta, Janelle Garrison, Charles C. Searby, Luk H. Vandenberghe, Seongjin Seo, Val C. Sheffield, Arlene V. Drack   +12 more
doaj   +1 more source

The Cone Dysfunction Syndromes [PDF]

, 2016
The cone dysfunction syndromes are a heterogeneous group of inherited, predominantly stationary retinal disorders characterised by reduced central vision, and varying degrees of colour vision abnormalities, nystagmus and photophobia.
Aboshiha, J, Carroll, J, Dubis, AM, Harcastle, AJ, Michaelides, M   +4 more
core  

Exposure to the complement C5b-9 complex sensitizes 661W photoreceptor cells to both apoptosis and necroptosis. [PDF]

, 2015
The loss of photoreceptors is the defining characteristic of many retinal degenerative diseases, but the mechanisms that regulate photoreceptor cell death are not fully understood.
Francesca Cordeiro, M, Guo, L, Moss, SE, Shi, H, Stampoulis, D, Williams, JA   +5 more
core   +1 more source

Repeatability of \u3cem\u3eIn Vivo\u3c/em\u3e Parafoveal Cone Density and Spacing Measurements [PDF]

, 2012
Purpose. To assess the repeatability and measurement error associated with cone density and nearest neighbor distance (NND) estimates in images of the parafoveal cone mosaic obtained with an adaptive optics scanning light ophthalmoscope (AOSLO).Methods ...
Carroll, Joseph, Cooper, Robert F., Dubis, Adam M., Dubra, Alfredo, Garrioch, Robert, Langlo, Christopher S.   +5 more
core   +1 more source

Cis-regulatory basis of sister cell type divergence in the vertebrate retina [PDF]

, 2019
Multicellular organisms evolved via repeated functional divergence of transcriptionally related sister cell types, but the mechanisms underlying sister cell type divergence are not well understood.
Corbo, Joseph C, Hughes, Andrew E.O., Lawrence, Karen A, Murphy, Daniel P, Myers, Connie A   +4 more
core   +3 more sources

The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision [PDF]

, 2017
Calcium (Ca2+) plays an important role in the function and health of neurons. In vertebrate cone photoreceptors, Ca2+ controls photoresponse sensitivity, kinetics, and light adaptation.
Arden, Bauer, Baylor, Berridge, Bronckers, Bronckers, Calvert, Corbo, Dizhoor, Fain, Gorczyca, Herzog, Hu, Hughes, Ingram, Jalloul, Kang, Korenbrot, Lamason, Lamb, Le, Li, Li, Makino, Mattapallil, Matthews, Matveev, Mendez, Miller, Nakatani, Neuillé, Nikonov, Nikonov, Palczewski, Parry, Picones, Poetsch, Prieto, Prinsen, Pugh, Rebrik, Reiländer, Riazuddin, Sakurai, Sakurai, Sakurai, Sampath, Sampath, Schnetkamp, Schwarzer, Schwarzer, Seymen, Shichida, Shirato, Smith, Stephan, Sulem, Szél, Tachibanaki, Takemoto, Tomizuka, Tsoi, Vinberg, Vinberg, Vinberg, Wang, Wang, Winkler, Yau, Yau   +69 more
core   +2 more sources

Docosahexaenoic acid promotes photoreceptor differentiation without altering Crx expression [PDF]

, 2006
PURPOSE: The precise molecular cues required for photoreceptor development are still unknown. Pax6 and Crx are essential during early retinal development and for photoreceptor differentiation, respectively.
Garelli, Andres, Politi, Luis Enrique, Rotstein, Nora Patricia   +2 more
core   +2 more sources

Modal content of living human cone photoreceptors

Biomedical Optics Express, 2015
Decades of experimental and theoretical investigations have established that photoreceptors capture light based on the principles of optical waveguiding. Yet considerable uncertainty remains, even for the most basic prediction as to whether photoreceptors support more than a single waveguide mode. To test for modal behavior in human cone photoreceptors
Zhuolin, Liu, Omer P, Kocaoglu, Timothy L, Turner, Donald T, Miller   +3 more
openaire   +2 more sources