Results 111 to 120 of about 3,348,916 (301)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Providing Intuition to the Fieller Method with Two Geometric Representations using STATA and Eviews [PDF]

The Fieller Method for the construction of confidence intervals for ratios of the expected value of two normally distributed random variables has been shown by a number of authors to be a superior method to the delta approximation.
J. N. Lye, J.G. Hirschberg
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Confidence interval of lifetime distribution using bootstrap method [PDF]

, 2008
Lifetime estimation is significant in engineering asset management. However, the estimate of lifetime or failure \ud time could be misleading as it may not reveal the real value.
Yu, Yi, Ma, Lin, Gu, YuanTong, Zhou, Yifan   +3 more
core  

Optimal confidence interval for the largest normal mean with unknown variance

, 2010
A single-sample procedure for obtaining an optimal confidence interval for the largest or smallest mean of several independent normal populations is proposed. It is assumed that the common variance is unknown.
陳順益; Chen, Shun-yi; Chen, Hubert J.
core   +1 more source

Robust Neighborhood Confidence Interval and Width to Evaluate the Outcome of a Binary Random Variable of Unequal Cluster Sizes

Journal of Biostatistics and Epidemiology
Bachground :While the main advantage of the confidence interval is that it enables more precise evaluations when the risk for the outcome of interest is related to the cluster size, the predicted confidence interval width demonstrates the degree of ...
Tareef Fadhil Raham, Zaher Fadhil Raham, Abdulkhaleq Abduljabbar Ali Ghalib Al-Naqeeb   +2 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Cooperative Interval Games Arising from Airport Situations with Interval Data [PDF]

This paper deals with the research area of cooperative interval games arising from airport situations with interval data. We also extend to airport interval games some results from classical theory.cooperative interval games;concave games;airport games ...
Brânzei, R., Tijs, S.H., Alparslan-Gok, S.Z.   +2 more
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Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Asymptotically distribution free (adf) interval estimation of coefficient alpha [PDF]

Asymptotic distribution free (ADF) interval estimators for coefficient alpha were introduced in the context of an application by Yuan, Guarnaccia, and Hayslip (2003). Here, simulation studies were performed to investigate the behavior of ADF vs.
ALBERTO MAYDEU
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