Results 111 to 120 of about 7,629,903 (299)
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
The optimal confidence region for a random parameter
Biometrika, 2005 Summary: Suppose that, under a two-level hierarchical model, the distribution of the vector of random parameters is known or can be estimated well. The data are generated via a fixed, but unobservable, realisations of the vector. We derive the smallest confidence region for a specific component of this random vector under a joint Bayesian/frequentist ...
Hajime Uno, Lu Tian, L.J. Wei
openaire +3 more sources
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
BMC Health Services ResearchBackground Public confidence is a cornerstone of effective healthcare delivery and the legitimacy of healthcare reform. In Ireland’s Health Service Executive (HSE) Mid-West (MW), Regional Health Area (RHA) E, ongoing concerns about access to care at ...
Sinéad M. Madden
doaj +1 more source
A stochastic approach to estimate distribution grid state with confidence regions
International Journal of Electrical Power & Energy SystemsMeasurement equipment located in electrical distribution grids, as power-quality measurement devices, substation meters, or customer smart meters do not provide phasor measurements due to the lack of high resolution time synchronization.
Rasmus L. Olsen +4 more
doaj +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Honest Confidence Regions for Nonparametric Regression
The Annals of Statistics, 1989 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Fixed Width Confidence Region for the Mean of a Multivariate Normal Distribution
, 2002 Srivastava gave an asymptotically efficient and consistent sequential procedure to obtain a fixed-width confidence region for the mean vector of any p-dimensional random vector with finite second moments.
H. Nagao, M. Srivastava
semanticscholar +1 more source